Dynamics and kinematics of viral protein linear nano-actuators for bio-nano robotic systems

A. Dubey; G. Sharma; C. Mavroidis; S. M. Tomassone; K. Nikitczuk; M. L. Yarmush

doi:10.1109/robot.2004.1308057

Dynamics and kinematics of viral protein linear nano-actuators for bio-nano robotic systems

A. Dubey, G. Sharma, C. Mavroidis, S. M. Tomassone, K. Nikitczuk, M. L. Yarmush

Research output: Contribution to journal › Conference article › peer-review

16 Scopus citations

Abstract

Dynamic and kinematic analysis is performed to predict and verify the performance of a new nanoscale biomolecular motor: The Viral Protein Linear (VPL) Motor. The motor is based on a conformational change observed in a family of viral envelope proteins when subjected to a changing pH enivronment. The conformational change produces a motion of about 10 nm, making the VPL a basic linear actuator which can be further interfaced with other organic/inorganic nanoscale components such as DNA actuators and carbon nanotubes. The proteins used in the motor are subjected to Molecular Dynamics simulation using the software called CHARMm (Chemistry at Harvard Molecular Mechanics). The results of dynamics are further verified by performing a set of kinematic simulations using direct and inverse kinematics methods.

Original language	English (US)
Pages (from-to)	1628-1633
Number of pages	6
Journal	Proceedings - IEEE International Conference on Robotics and Automation
Volume	2004
Issue number	2
DOIs	https://doi.org/10.1109/robot.2004.1308057
State	Published - 2004
Event	Proceedings- 2004 IEEE International Conference on Robotics and Automation - New Orleans, LA, United States Duration: Apr 26 2004 → May 1 2004

All Science Journal Classification (ASJC) codes

Software
Artificial Intelligence
Electrical and Electronic Engineering
Control and Systems Engineering

Keywords

Bionano Robotics
Molecular Dynamics
Molecular Kinematics
Molecular Motors

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10.1109/robot.2004.1308057

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title = "Dynamics and kinematics of viral protein linear nano-actuators for bio-nano robotic systems",

abstract = "Dynamic and kinematic analysis is performed to predict and verify the performance of a new nanoscale biomolecular motor: The Viral Protein Linear (VPL) Motor. The motor is based on a conformational change observed in a family of viral envelope proteins when subjected to a changing pH enivronment. The conformational change produces a motion of about 10 nm, making the VPL a basic linear actuator which can be further interfaced with other organic/inorganic nanoscale components such as DNA actuators and carbon nanotubes. The proteins used in the motor are subjected to Molecular Dynamics simulation using the software called CHARMm (Chemistry at Harvard Molecular Mechanics). The results of dynamics are further verified by performing a set of kinematic simulations using direct and inverse kinematics methods.",

keywords = "Bionano Robotics, Molecular Dynamics, Molecular Kinematics, Molecular Motors",

author = "A. Dubey and G. Sharma and C. Mavroidis and Tomassone, {S. M.} and K. Nikitczuk and Yarmush, {M. L.}",

year = "2004",

doi = "10.1109/robot.2004.1308057",

language = "English (US)",

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journal = "Proceedings - IEEE International Conference on Robotics and Automation",

issn = "1050-4729",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "2",

note = "Proceedings- 2004 IEEE International Conference on Robotics and Automation ; Conference date: 26-04-2004 Through 01-05-2004",

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T1 - Dynamics and kinematics of viral protein linear nano-actuators for bio-nano robotic systems

AU - Dubey, A.

AU - Sharma, G.

AU - Mavroidis, C.

AU - Tomassone, S. M.

AU - Nikitczuk, K.

AU - Yarmush, M. L.

PY - 2004

Y1 - 2004

N2 - Dynamic and kinematic analysis is performed to predict and verify the performance of a new nanoscale biomolecular motor: The Viral Protein Linear (VPL) Motor. The motor is based on a conformational change observed in a family of viral envelope proteins when subjected to a changing pH enivronment. The conformational change produces a motion of about 10 nm, making the VPL a basic linear actuator which can be further interfaced with other organic/inorganic nanoscale components such as DNA actuators and carbon nanotubes. The proteins used in the motor are subjected to Molecular Dynamics simulation using the software called CHARMm (Chemistry at Harvard Molecular Mechanics). The results of dynamics are further verified by performing a set of kinematic simulations using direct and inverse kinematics methods.

AB - Dynamic and kinematic analysis is performed to predict and verify the performance of a new nanoscale biomolecular motor: The Viral Protein Linear (VPL) Motor. The motor is based on a conformational change observed in a family of viral envelope proteins when subjected to a changing pH enivronment. The conformational change produces a motion of about 10 nm, making the VPL a basic linear actuator which can be further interfaced with other organic/inorganic nanoscale components such as DNA actuators and carbon nanotubes. The proteins used in the motor are subjected to Molecular Dynamics simulation using the software called CHARMm (Chemistry at Harvard Molecular Mechanics). The results of dynamics are further verified by performing a set of kinematic simulations using direct and inverse kinematics methods.

KW - Bionano Robotics

KW - Molecular Dynamics

KW - Molecular Kinematics

KW - Molecular Motors

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DO - 10.1109/robot.2004.1308057

M3 - Conference article

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EP - 1633

JO - Proceedings - IEEE International Conference on Robotics and Automation

JF - Proceedings - IEEE International Conference on Robotics and Automation

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Y2 - 26 April 2004 through 1 May 2004

ER -

Dynamics and kinematics of viral protein linear nano-actuators for bio-nano robotic systems

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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