Dynamics of Helicobacter pylori colonization in relation to the host response

Martin J. Blaser, Denise Kirschner

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

The dynamics of Helicobacter pylori colonization from its acquisition through the development of steady-state are examined through a mathematical model that includes the host response. The model encompasses both host and microbiological variation. The individual capacity of the host response is shown to be a key model parameter, leading to either transient or persistent colonization, whereas the growth rate of that response has little effect. Analyses of competing strains indicate that each must occupy a specific niche, otherwise exclusion occurs. The model implies that there exists a lower bound on the host response to the indigenous microflora that is consistent with current biological views of H. pylori. Parallel models may be useful in understanding other persistent host-microbial interactions.

Original languageEnglish (US)
Pages (from-to)8359-8364
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number15
DOIs
StatePublished - Jul 20 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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