TY - JOUR
T1 - Dysarthria in individuals with Parkinson's disease
T2 - A protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark)
AU - Pinto, Serge
AU - Cardoso, Rita
AU - Sadat, Jasmin
AU - Guimarães, Isabel
AU - Mercier, Céline
AU - Santos, Helena
AU - Atkinson-Clement, Cyril
AU - Carvalho, Joana
AU - Welby, Pauline
AU - Oliveira, Pedro
AU - D'Imperio, Mariapaola
AU - Frota, Sónia
AU - Letanneux, Alban
AU - Vigario, Marina
AU - Cruz, Marisa
AU - Martins, Isabel Pavão
AU - Viallet, François
AU - Ferreira, Joaquim J.
N1 - Publisher Copyright:
© 2016 Published by the BMJ Publishing Group Limited.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Introduction: Individuals with Parkinson's disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese). Methods and analysis: Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life. Ethics and dissemination: The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable large-scale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results: will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided.
AB - Introduction: Individuals with Parkinson's disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese). Methods and analysis: Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life. Ethics and dissemination: The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable large-scale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results: will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided.
KW - Cross-language
KW - Disease progression
KW - Dysarthria
KW - Parkinson's disease
KW - Pharmacological treatment
KW - Speech
UR - https://www.scopus.com/pages/publications/84996844579
UR - https://www.scopus.com/pages/publications/84996844579#tab=citedBy
U2 - 10.1136/bmjopen-2016-012885
DO - 10.1136/bmjopen-2016-012885
M3 - Article
C2 - 27856480
AN - SCOPUS:84996844579
SN - 2044-6055
VL - 6
JO - BMJ open
JF - BMJ open
IS - 11
M1 - e012885
ER -