Dysgammaglobulinemia in steroid-dependent optic neuritis: Response to gammaglobulin treatment

L. P. Frohman, L. P. Frohman, S. D. Cook, L. Bielory

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


At the age of 12, a prematurely born boy with an otherwise unremarkable past medical history developed bilateral optic neuritis associated with transverse myelopathy. Over the ensuing 3 years, recurrent bouts of optic neuritis OU, with dyschromatopsia, and acuity and field loss (arcuate, central, and paracentral scotomas) were controlled with increasing doses of corticosteroids. However, the patient became steroid-dependent and experienced recurrent optic neuritis during multiple attempts at tapering the steroids. He developed optic atrophy and steroid complications, including cushingnoid features and growth maturation delay. Immunoglobulin G subclass 2 and 3 deficiencies were the only serologically detectable abnormalities. Administration of intravenous gammaglobulin (25 g monthly) allowed discontinuation of steroids without further ophthalmic or neurologic disease. Following steroid withdrawal and institution of gammaglobulin, the patient grew 6 inches within 2 years, regaining his vision, retrieving his stature, and normalizing his psychosocial development.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalJournal of Clinical Neuro-Ophthalmology
Issue number4
StatePublished - Dec 1991

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Clinical Neurology


  • Dysgammaglobulinemia
  • Optic neuritis
  • Steroids


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