E2F-1 as an anticancer drug target

Joseph Bertino, Debabrata Banerjee

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Mounting evidence indicates that the E2F transcription factors play an essential role in all aspects of cellular functions. Many human malignancies have been shown to overexpress one or more of the "activating" E2Fs. In some circumstances, down regulation as well as overexpression of E2F-1, leads to inhibition of cell growth. The emphasis in this review is placed on new data implicating microRNAs in the regulation of E2F activity and the efforts thus far to target this activity in order to cause tumor regression.

Original languageEnglish (US)
Pages (from-to)207-214
Number of pages8
JournalOncology Reviews
Volume3
Issue number4
DOIs
StatePublished - Dec 1 2009

Fingerprint

E2F Transcription Factors
MicroRNAs
Pharmaceutical Preparations
Neoplasms
Down-Regulation
Growth

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Cancer
  • E2F-1
  • MicroRNAs
  • Retinoblastoma protein

Cite this

Bertino, Joseph ; Banerjee, Debabrata. / E2F-1 as an anticancer drug target. In: Oncology Reviews. 2009 ; Vol. 3, No. 4. pp. 207-214.
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E2F-1 as an anticancer drug target. / Bertino, Joseph; Banerjee, Debabrata.

In: Oncology Reviews, Vol. 3, No. 4, 01.12.2009, p. 207-214.

Research output: Contribution to journalReview article

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AU - Banerjee, Debabrata

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AB - Mounting evidence indicates that the E2F transcription factors play an essential role in all aspects of cellular functions. Many human malignancies have been shown to overexpress one or more of the "activating" E2Fs. In some circumstances, down regulation as well as overexpression of E2F-1, leads to inhibition of cell growth. The emphasis in this review is placed on new data implicating microRNAs in the regulation of E2F activity and the efforts thus far to target this activity in order to cause tumor regression.

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KW - MicroRNAs

KW - Retinoblastoma protein

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