Early changes in blood brain barrier permeability to small molecules after transient cerebral ischemia

Jacob Sage, R. L. Van Uitert, T. E. Duffy

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Brain unidirectional extraction and flux of leucine were measured simultaneously with cerebral blood flow (CBF) at various times after transient global cerebral ischemia in the rat. The results permit an evaluation of blood-brain barrier permeability in the post ischemic period independent of alterations in CBF at the time of measurement. Leucine extraction was higher (p < 0.001) than that of CBF-matched controls at 15 min and 6 hr after 30 min of global cerebral ischemia, but was not different from control at 30 min and 1 h after ischemia. Leucine flux into brain was increased only at 15 min after reperfusion of the brain. Cerebral edema occurs 15-30 min after reperfusion in this ischemia model, but the permeability of the blood-brain barrier to large molecules is unaltered during this period (Petito et al: J Neuropath Exp Neurol 41:423-436, 1982). Increased barrier permeability to small molecules such as leucine may contribute to the production of this early postischemic edema.

Original languageEnglish (US)
Pages (from-to)46-50
Number of pages5
JournalStroke
Volume15
Issue number1
DOIs
StatePublished - 1984

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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