@article{4bf598793d1049b9955cad4540f5fd60,
title = "Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition",
abstract = "There are few studies of environmental factors in familial forms of schizophrenia. We investigated whether childhood adversity or environmental factors were associated with schizophrenia in a familial sample where schizophrenia is associated with the . NOSA1P gene. We found that a cumulative adversity index including childhood illness, family instability and cannabis use was significantly associated with narrow schizophrenia, independent of . NOSA1P risk genotype, previously measured childhood trauma, covariates and familial clustering (adjusted odds ratio (95% confidence interval). =. 1.55 (1.01, 2.38)). The results provide further support that early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition.",
keywords = "Childhood adversity, Early trauma, Familial schizophrenia, Genetic predisposition, Risk factor",
author = "Husted, {Janice A.} and Rashid Ahmed and Chow, {Eva W.C.} and Brzustowicz, {Linda M.} and Bassett, {Anne S.}",
note = "Funding Information: This work was supported by grants from the Canadian Institutes of Health Research ( MOP-53216 ) and by National Alliance for Research on Depression and Schizophrenia (NARSAD) Distinguished Investigator Award (A.S.B.) , the National Institute of Mental Health ( R01 MH62440 ) and NARSAD Staglin Family Music Festival Schizophrenia Research Award (L.M.B.) and NARSAD Independent Investigator Award (J.A.H.) and the Canada Research Chair in Schizophrenia Genetics(A.S.B.). The authors thank the families for their long termparticipation in the study, Alex Shaw, Nandita Sawh and Brad Reimann for their data abstraction and Gladys Wong and Monica Torsanfor their assistance in the preparation of the manuscript. Funding Information: This work was supported by grants from the Canadian Institutes of Health Research (MOP-53216) and by National Alliance for Research on Depression and Schizophrenia (NARSAD) Distinguished Investigator Award (A.S.B.), the National Institute of Mental Health (R01 MH62440) and NARSAD Staglin Family Music Festival Schizophrenia Research Award (L.M.B.) and NARSAD Independent Investigator Award (J.A.H.) and the Canada Research Chair in Schizophrenia Genetics(A.S.B.). ",
year = "2012",
month = may,
doi = "10.1016/j.schres.2012.02.009",
language = "English (US)",
volume = "137",
pages = "166--168",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",
}