Early-life influences on obesity: From preconception to adolescence

Mark L. Wahlqvist, Stephen A. Krawetz, Nico S. Rizzo, Maria Gloria Dominguez-Bello, Linda M. Szymanski, Shari Barkin, Ann Yatkine, Robert A. Waterland, Julie A. Mennella, Mina Desai, Michael G. Ross, Nancy F. Krebs, Bridget E. Young, Jane Wardle, Christiane D. Wrann, John G. Kral

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


The double burden of under- and overnutrition profoundly affects human health globally. According to the World Health Organization, obesity and diabetes rates have almost doubled worldwide since 1980, and, in 2011, more than 40 million children under 5 years of age were overweight. Ecologic factors, parental genetics and fitness, and the intrauterine environment significantly influence the likelihood of offspring developing the dysmetabolic diathesis of obesity. This report examines the effects of these factors, including preconception, intrauterine and postnatal energy balance affecting programming of transgenerational transmission, and development of chronic diseases later in life-in particular, diabesity and its comorbidities.

Original languageEnglish (US)
Pages (from-to)1-28
Number of pages28
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


  • Breast feeding
  • Diabesity
  • Econutritional
  • Epigenetics
  • Exercise
  • Microbiome
  • Nutrition
  • Obesity
  • Taste preferences


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