Early origins of disease

D. B. Hardy; D. J. Hoffman

doi:10.1016/B978-0-12-821848-8.00030-5

Early origins of disease

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Epidemiologic and clinical research now provide strong support for the developmental origins of health and disease (DOHaD), which suggests that nutritional insults in utero can lead to long-term metabolic in postnatal life. Animal models have further elucidated the underlying potential epigenetic, metabolic, and endocrine mechanisms behind DOHaD. This article presents a summary of current clinical and animal research that supports the concept of DOHaD, as well as potential mechanisms and interactions that explain how nutrition in utero can impact short-term fetal development and long-term health in postnatal life.

Original language	English (US)
Title of host publication	Encyclopedia of Human Nutrition
Subtitle of host publication	Volume 1-4, Fourth Edition
Publisher	Elsevier
Pages	50-57
Number of pages	8
Volume	1-4
ISBN (Electronic)	9780323908160
DOIs	https://doi.org/10.1016/B978-0-12-821848-8.00030-5
State	Published - Jan 1 2023
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Engineering
General Agricultural and Biological Sciences

Keywords

DNA methylation
Developmental origins of health and disease (DOHaD)
Dyslipidemia
Epigenetics
Fatty liver disease
Intrauterine growth restriction (IUGR)
Oxidative stress
Placental insufficiency
Postnatal catch-up growth
Posttranslational histone modifications
Type 2 diabetes
microRNAs

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10.1016/B978-0-12-821848-8.00030-5

Cite this

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abstract = "Epidemiologic and clinical research now provide strong support for the developmental origins of health and disease (DOHaD), which suggests that nutritional insults in utero can lead to long-term metabolic in postnatal life. Animal models have further elucidated the underlying potential epigenetic, metabolic, and endocrine mechanisms behind DOHaD. This article presents a summary of current clinical and animal research that supports the concept of DOHaD, as well as potential mechanisms and interactions that explain how nutrition in utero can impact short-term fetal development and long-term health in postnatal life.",

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AU - Hoffman, D. J.

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AB - Epidemiologic and clinical research now provide strong support for the developmental origins of health and disease (DOHaD), which suggests that nutritional insults in utero can lead to long-term metabolic in postnatal life. Animal models have further elucidated the underlying potential epigenetic, metabolic, and endocrine mechanisms behind DOHaD. This article presents a summary of current clinical and animal research that supports the concept of DOHaD, as well as potential mechanisms and interactions that explain how nutrition in utero can impact short-term fetal development and long-term health in postnatal life.

KW - DNA methylation

KW - Developmental origins of health and disease (DOHaD)

KW - Dyslipidemia

KW - Epigenetics

KW - Fatty liver disease

KW - Intrauterine growth restriction (IUGR)

KW - Oxidative stress

KW - Placental insufficiency

KW - Postnatal catch-up growth

KW - Posttranslational histone modifications

KW - Type 2 diabetes

KW - microRNAs

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M3 - Chapter

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VL - 1-4

SP - 50

EP - 57

BT - Encyclopedia of Human Nutrition

PB - Elsevier

ER -

Early origins of disease

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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