Abstract
The effect of altered urinary p H on the excretion of single doses of orally administered tetracycline hydrochloride and doxycycline hyclate was studied in humans. Alkalinization of the urine significantly enhanced the cumulative renal excretion of both tetracycline and doxycycline as compared to acidic urine treatments. Altered tubular reabsorption was assumed to have caused this effect, since tetracyclines have been shown to be more lipid soluble at their isoelectric p H (approximately the p H of the acidic urine treatment) as compared to more alkaline p Hs. The renal clearance of doxycycline was significantly increased by urinary alkalinization.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 267-282 |
| Number of pages | 16 |
| Journal | Journal of Pharmacokinetics and Biopharmaceutics |
| Volume | 1 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1973 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Pharmacology, Toxicology and Pharmaceutics
- Pharmacology (medical)
Keywords
- doxycycline hyclate
- excretion
- tetracycline hydrochloride
- urinary pH