Effect of amphetamine on cerebral blood flow and capillary perfusion

Karen E. Russo, Wyatt Hall, Oak Z. Chi, Arabinda K. Sinha, Harvey R. Weiss

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The purpose of this study was to determine the cerebral regional microvascular and vascular responses to amphetamine sulfate at a dose (5 mg/kg) known to affect neuronal function. Cerebral blood flow (14C-iodoantipyrine method) and percent of perfused capillaries (fluorescein isothiocyanate-dextran and alkaline phosphatase staining method) were determined during control and after intravenous administration of amphetamine in conscious Long-Evans rats. Amphetamine caused an increase in blood pressure (34%) and heart rate (31%). There was a significant increase in averaged cerebral blood flow from 98 ±8to 166±9 ml/min/100 g after amphetamine. This flow increase was significant in the cortex, basal ganglia, pons and medulla, however the increase was not significant in the hypothalamus. In control rats, there were approximately 325 ± 17 capillaries/mm2 of brain tissue and 52 ± 1% of them were perfused. Amphetamine increased the percent perfused significantly to 72 ± 1% in all examined regions. There was a similar significant increase in the percent of perfused cerebral capillary volume fraction. There were both vascular and microvascular responsesto amphetamine, increasing cerebral blood flow as well as reducing the diffusion distance for oxygen.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalBrain research
Volume542
Issue number1
DOIs
StatePublished - Feb 22 1991

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Amphetamine
  • Cerebral blood flow
  • Cerebral capillary
  • Rat

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