Effect of C-reactive protein on granulocyte-macrophage progenitor cells

John F. Marcelletti, Candace S. Johnson, Richard F. Mortensen, Philip Furmanski

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Pathophysiological concentrations of CRP inhibited the in vitro clonal proliferation of CFU-C's. CRP inhibition was specific for normal CFU-C's committed to the mononuclear phagocyte lineage. Macrophage progenitor cells stimulated by an inflammatory response were unaffected by CRP. CFU-C's which were committed to the granulocyte lineage, those which gave rise to both macrophages and granulocytes, and erythroid progenitor cells were also not affected by CRP. Only macrophage CFU-C's that possessed Fc receptors and were in S-phase at the time of CRP exposure were susceptible to inhibition of colony formation. The data suggest that CRP functions as a regulator of the cellular composition of an inflammatory response.

Original languageEnglish (US)
Pages (from-to)70-80
Number of pages11
JournalThe Journal of Laboratory and Clinical Medicine
Volume100
Issue number1
StatePublished - Jul 1982

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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