Effect of cholesterol α and β epoxides on cell killing and transformation

G. Peter Raaphorst, Edouard I. Azzam, Rejean Langlois, Johan E. Van Lier

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

V-79 Chinese hamster lung fibroblasts and C3H-10T1/2 mouse embryo cells were used to study the toxicity and transformation effects of the 5α, 6α-, and 5β, 6β-epoxy derivatives of cholesterol. Both epoxides were found to be carcinogenic, and the transformation frequency increased with epoxide concentration and exposure time. The 5β, 6β-epoxide caused a higher level of transformation than the α-isomer, and this is consistent with its greater toxicity.

Original languageEnglish (US)
Pages (from-to)2369-2372
Number of pages4
JournalBiochemical Pharmacology
Volume36
Issue number14
DOIs
StatePublished - Jul 15 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology

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