TY - JOUR
T1 - Effect of chronic infusion of placental lactogen on ovine fetal growth in late gestation
AU - Schoknecht, P. A.
AU - McGuire, M. A.
AU - Cohick, W. S.
AU - Currie, W. B.
AU - Bell, A. W.
N1 - Funding Information:
The technical assistance of Ramona Slepetis and Suzanne Nobrega is gratefully acknowledged. This study was supported by the New York Agricultural Experiment Station. Reprint requests, correspondence, and proofs should be sent to Dr. A.W. Bell, Dept of Animal Science, 262 Morrison Hall, Cornell University, Ithaca, NY 14853-4801. Phone: (607) 255-2873. FAX: (607) 2559829. e-mail: [email protected].
PY - 1996/11
Y1 - 1996/11
N2 - To test the hypothesis that placental lactogen (PL) is a humoral regulator of fetal growth, six singleton sheep fetuses received a continuous intravenous fusion of 1.2 mg/d of purified ovine PL (oPL) for 14 d, beginning on Day 122 of gestation. The plasma concentration of oPL was approximately four-fold higher in infused fetuses than in six control fetuses that received a continuous infusion of saline. The circulating insulin-like growth factor 1 (IGF-1) concentration was also significantly elevated in PL-infused fetuses (43.1 ± 1.7 vs. 31.9 ± 4.1 ng/ml; P < 0.05). Animals were slaughtered on Day 136, and the placenta and all major fetal tissues were dissected, weighed, and subsampled for chemical analysis. Fetal weight and crown-rump length were not significantly affected by treatment; however, the aggregate weight of the brain, liver, lungs, and heart tended to be larger (85.3 ± 2.1 vs. 79.9 ± 1.5 g/kg fetus; mean ± SE, P = 0.07) and the thyroid gland was smaller (0.18 ± 0.1 vs. 0.26 ± 0.02 g/kg fetus: P < 0.05) in the PL-infused fetuses. The livers of the PL infused fetuses had also accumulated additional glycogen (13.1 ± 1.7 vs. 8.4 ± 0.7 g; P < 0.05). In late gestation, PL within the fetal compartment increases fetal plasma IGF-1 concentration and hepatic glycogen deposition and may affect the growth of several vital organs.
AB - To test the hypothesis that placental lactogen (PL) is a humoral regulator of fetal growth, six singleton sheep fetuses received a continuous intravenous fusion of 1.2 mg/d of purified ovine PL (oPL) for 14 d, beginning on Day 122 of gestation. The plasma concentration of oPL was approximately four-fold higher in infused fetuses than in six control fetuses that received a continuous infusion of saline. The circulating insulin-like growth factor 1 (IGF-1) concentration was also significantly elevated in PL-infused fetuses (43.1 ± 1.7 vs. 31.9 ± 4.1 ng/ml; P < 0.05). Animals were slaughtered on Day 136, and the placenta and all major fetal tissues were dissected, weighed, and subsampled for chemical analysis. Fetal weight and crown-rump length were not significantly affected by treatment; however, the aggregate weight of the brain, liver, lungs, and heart tended to be larger (85.3 ± 2.1 vs. 79.9 ± 1.5 g/kg fetus; mean ± SE, P = 0.07) and the thyroid gland was smaller (0.18 ± 0.1 vs. 0.26 ± 0.02 g/kg fetus: P < 0.05) in the PL-infused fetuses. The livers of the PL infused fetuses had also accumulated additional glycogen (13.1 ± 1.7 vs. 8.4 ± 0.7 g; P < 0.05). In late gestation, PL within the fetal compartment increases fetal plasma IGF-1 concentration and hepatic glycogen deposition and may affect the growth of several vital organs.
UR - http://www.scopus.com/inward/record.url?scp=0030293652&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030293652&partnerID=8YFLogxK
U2 - 10.1016/S0739-7240(96)00090-2
DO - 10.1016/S0739-7240(96)00090-2
M3 - Article
C2 - 8960408
AN - SCOPUS:0030293652
SN - 0739-7240
VL - 13
SP - 519
EP - 528
JO - Domestic Animal Endocrinology
JF - Domestic Animal Endocrinology
IS - 6
ER -