Effect of cyclosporine treatment on carnitine and myo-inositol in diabetic rats

A. S. Reddi, G. N. Jyothirmayi, C. B. Leevy, M. Khalil, B. DeAngelis, O. Frank, H. Baker

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

1. The effect of long-term (20 wk) treatment of cyclosporine A (CyA) was studied in urine, blood, liver, kidney and pancreatic concentrations of acid-soluble carnitine and free myo-inositol in streptozotocin diabetic rats. 2. Diabetic rats excreted significantly higher concentrations of carnitine and myo-inositol; CyA prevented the urinary loss of carnitine but not myo-inositol. 3. Blood carnitine levels were not different between normal and diabetic rats, however, CyA significantly decreased these levels. Conversely, blood myo-inositol concentrations were higher in diabetic than in normal rats; CyA prevented this increase. 4. Hepatic concentrations of both carnitine and myo-inositol were increased in diabetic rats; CyA treatment caused even further increase. 5. Pancreas from diabetic rats contained less carnitine and myo-inositol compared to normal pancreas. CyA treatment did not affect pancreatic carnitine, but it normalized myo-inositol in diabetic rats. 6. The kidney carnitine or myo-inositol levels were not influenced either by diabetes or by CyA treatment. 7. These results suggest that CyA treatment causes changes in carnitine and myo-inositol concentrations in biologic fluids and certain tissues.

Original languageEnglish (US)
Pages (from-to)151-153
Number of pages3
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume101
Issue number1
DOIs
StatePublished - Jan 1992

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology

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