Effect of ebrotidine on gastric mucosal EGF and PDGF receptor expression

J. Piotrowski, A. Czajkowski, F. Yotsumoto, A. Slomiany, B. L. Slomiany

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The effect of ebrotidine, a new H2-blocker with gastroprotective properties, on the expression of gastric mucosal epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) receptors, was investigated. Mucosal cell membranes were isolated from rats receiving twice daily for 5 days a dose of 100mg/kg ebrotidine or 100mg/kg ranitidine or vehicle only. Assays for EGF and PDGF revealed the presence of both types of receptors, activation of which led to enhanced tyrosine kinase activity. The receptor binding values in the control group were 2.4 fmol for EGF and 1.45 fmol/mg protein for PDGF, whereas the values in the ebrotidine group increased for EGF by 65.7% and 38.6% for PDGF, but no such effect was observed with ranitidine. The results suggest that the gastroprotective properties of ebrotidine stem from its ability to stimulate the epithelial proliferative activities through the enhancement of EGF and PDGF receptors expression.

Original languageEnglish (US)
Pages (from-to)1127-1134
Number of pages8
JournalBiochemistry and Molecular Biology International
Volume30
Issue number6
StatePublished - Jan 1 1993

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

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