Effect of exertion on the stimulation of ornithine decarboxylase activity by growth hormone in rats

Joseph V. Martin, Richard Jed Wyatt, Wallace B. Mendelson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

To investigate the effect of stressful stimulation on tissue responsiveness to growth hormone (GH), we examined ODC activity as a measure of hepatic sensitivity to the hormone during forced exertion in rats. GH caused a 15-fold increase in ODC activity in the livers of resting rats at 3 hours after the injection of hormone. Forced walking in a rotating cylinder enhanced the effect of GH on ODC activity by up to 66% above the effect in resting rats, and this enhancement was positively related to the speed of rotation of the cylinder. These results suggest that tissue hypersensitivity to GH stimulation is a consequence of forced exertion. This hypersensitivity to GH would tend to compensate for the inhibitory effects of forced exertion on GH secretion in rats.

Original languageEnglish (US)
Pages (from-to)1871-1875
Number of pages5
JournalLife Sciences
Volume44
Issue number24
DOIs
StatePublished - 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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