Abstract
When Mycobacterium bovis BCG and Staphylococcus aureus were plated on agar containing increasing concentrations of fluoroquinolone, colony numbers exhibited a sharp drop, followed by a plateau and a second sharp drop. The plateau region correlated with the presence of first-step resistant mutants. Mutants were not recovered at concentrations above those required for the second sharp drop, thereby defining a mutant prevention concentration (MPC). A C-8-methoxy group lowered the MPC for an N-1-cyclopropyl fluoroquinolone.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1756-1758 |
| Number of pages | 3 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 43 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1999 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases