Effect of hypothalamic stimulation on mesencephalic neurons

Henry M. Edinger; Stanley Z. Kramer; Allan Siegel

doi:10.1016/0014-4886(77)90237-0

Effect of hypothalamic stimulation on mesencephalic neurons

Henry M. Edinger, Stanley Z. Kramer, Allan Siegel

New Jersey Medical School (NJMS), Pharmacology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The purpose of this study was to determine the effect of electrical stimulation of the lateral hypothalamus and preoptic area on second- and higher-order neurons in the ventral tegmental area of the mesencephalon. Single-unit responses were recorded by tungsten microelectrodes in anesthetized cats. Lateral hypothalamic stimulation caused short- and long-latency excitation as well as antidromic activation of ventral tegmental area neurons. However, half of the responsive neurons exhibited a suppression of firing, or inhibition, following stimulation. The short latency of onset of the suppression obtained in some of these neurons suggests the possibility that, in addition to a descending excitatory hypothalamic outflow, descending monosynaptic inhibitory pathways to the ventral tegmental area are also present.

Original language	English (US)
Pages (from-to)	91-103
Number of pages	13
Journal	Experimental Neurology
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/0014-4886(77)90237-0
State	Published - Jan 1977

All Science Journal Classification (ASJC) codes

Neurology
Developmental Neuroscience

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title = "Effect of hypothalamic stimulation on mesencephalic neurons",

abstract = "The purpose of this study was to determine the effect of electrical stimulation of the lateral hypothalamus and preoptic area on second- and higher-order neurons in the ventral tegmental area of the mesencephalon. Single-unit responses were recorded by tungsten microelectrodes in anesthetized cats. Lateral hypothalamic stimulation caused short- and long-latency excitation as well as antidromic activation of ventral tegmental area neurons. However, half of the responsive neurons exhibited a suppression of firing, or inhibition, following stimulation. The short latency of onset of the suppression obtained in some of these neurons suggests the possibility that, in addition to a descending excitatory hypothalamic outflow, descending monosynaptic inhibitory pathways to the ventral tegmental area are also present.",

author = "Edinger, {Henry M.} and Kramer, {Stanley Z.} and Allan Siegel",

note = "Funding Information: 1 This investigation \vas hupported by Sational Institutes of Health Grant KS 07941-07 and by a grant from the Foundation of the College of Medicine and Dentistry of Ke\v Jersey. The authors thank Als. Susan Torres for her expert technical assistance and Ms. Christina Hammerle for typing the manuscript.",

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T1 - Effect of hypothalamic stimulation on mesencephalic neurons

AU - Edinger, Henry M.

AU - Kramer, Stanley Z.

AU - Siegel, Allan

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PY - 1977/1

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N2 - The purpose of this study was to determine the effect of electrical stimulation of the lateral hypothalamus and preoptic area on second- and higher-order neurons in the ventral tegmental area of the mesencephalon. Single-unit responses were recorded by tungsten microelectrodes in anesthetized cats. Lateral hypothalamic stimulation caused short- and long-latency excitation as well as antidromic activation of ventral tegmental area neurons. However, half of the responsive neurons exhibited a suppression of firing, or inhibition, following stimulation. The short latency of onset of the suppression obtained in some of these neurons suggests the possibility that, in addition to a descending excitatory hypothalamic outflow, descending monosynaptic inhibitory pathways to the ventral tegmental area are also present.

AB - The purpose of this study was to determine the effect of electrical stimulation of the lateral hypothalamus and preoptic area on second- and higher-order neurons in the ventral tegmental area of the mesencephalon. Single-unit responses were recorded by tungsten microelectrodes in anesthetized cats. Lateral hypothalamic stimulation caused short- and long-latency excitation as well as antidromic activation of ventral tegmental area neurons. However, half of the responsive neurons exhibited a suppression of firing, or inhibition, following stimulation. The short latency of onset of the suppression obtained in some of these neurons suggests the possibility that, in addition to a descending excitatory hypothalamic outflow, descending monosynaptic inhibitory pathways to the ventral tegmental area are also present.

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JO - Experimental Neurology

JF - Experimental Neurology

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Effect of hypothalamic stimulation on mesencephalic neurons

Abstract

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