Effect of inspiratory resistance and theophylline on respiratory muscle strength in patients with amyotrophic lateral sclerosis

P. L. Schiffman, Jerry Belsh

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The effect of breathing through inspiratory flow resistive loads ranging between 4.5 and 27.0 cm H2O/L/s was assessed in eight patients with amyotrophic lateral sclerosis (ALS) and in eight control subjects. ALS patients developed respiratory muscle fatigue manifested by significant declines in negative inspiratory pressure (18.3%), vital capacity (7.2%), and peak inspiratory flow rate (5.5%). Control subjects did not fatigue with these resistances. In ALS patients, theophylline increased respiratory muscle strength after resistive breathing as manifested by an increase in negative inspiratory pressure (28.2%), vital capacity (10%), and peak inspiratory flow rate (11.8%). It is concluded that in patients with ALS, the already weakened respiratory muscles are easily fatigued. Furthermore, theophylline can strengthen loaded respiratory muscles in patients with ALS.

Original languageEnglish (US)
Pages (from-to)1418-1423
Number of pages6
JournalAmerican Review of Respiratory Disease
Volume139
Issue number6
DOIs
StatePublished - Jan 1 1989

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Respiratory Muscles
Amyotrophic Lateral Sclerosis
Muscle Strength
Theophylline
Vital Capacity
Respiration
Pressure
Muscle Fatigue
Fatigue

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

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abstract = "The effect of breathing through inspiratory flow resistive loads ranging between 4.5 and 27.0 cm H2O/L/s was assessed in eight patients with amyotrophic lateral sclerosis (ALS) and in eight control subjects. ALS patients developed respiratory muscle fatigue manifested by significant declines in negative inspiratory pressure (18.3{\%}), vital capacity (7.2{\%}), and peak inspiratory flow rate (5.5{\%}). Control subjects did not fatigue with these resistances. In ALS patients, theophylline increased respiratory muscle strength after resistive breathing as manifested by an increase in negative inspiratory pressure (28.2{\%}), vital capacity (10{\%}), and peak inspiratory flow rate (11.8{\%}). It is concluded that in patients with ALS, the already weakened respiratory muscles are easily fatigued. Furthermore, theophylline can strengthen loaded respiratory muscles in patients with ALS.",
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Effect of inspiratory resistance and theophylline on respiratory muscle strength in patients with amyotrophic lateral sclerosis. / Schiffman, P. L.; Belsh, Jerry.

In: American Review of Respiratory Disease, Vol. 139, No. 6, 01.01.1989, p. 1418-1423.

Research output: Contribution to journalArticle

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