Effect of interferon beta-1a on B7.1 and B7.2 B-cell expression and its impact on T-cell proliferation

Hui Huang, Kouichi Ito, Fernando Dangond, Suhayl Dhib-Jalbut

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The effect of pharmacologically relevant doses of interferon (IFN) β-1a on B-cell expression of B7.1 and B7.2 was investigated. Culture of peripheral blood mononuclear cells with IFN β-1a 100. IU/mL decreased B-cell expression of B7.1 and increased B7.2 expression. Interleukin-10 in B cells was significantly enhanced by IFN β-1a. Anti-CD3 and anti-CD28 monoclonal antibody-mediated T-cell proliferations were partially suppressed in the presence of B cells pretreated with IFN β-1a. These data suggest that IFN β-1a and B cells can interact to play a beneficial role in the treatment of multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalJournal of Neuroimmunology
Volume258
Issue number1-2
DOIs
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Keywords

  • B cell
  • B7.2
  • Costimulation
  • Interferon beta
  • Multiple sclerosis
  • Peripheral blood mononuclear cell

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