Effect of interferon beta-1a on B7.1 and B7.2 B-cell expression and its impact on T-cell proliferation

Hui Huang; Kouichi Ito; Fernando Dangond; Suhayl Dhib-Jalbut

doi:10.1016/j.jneuroim.2013.02.010

Effect of interferon beta-1a on B7.1 and B7.2 B-cell expression and its impact on T-cell proliferation

Hui Huang, Kouichi Ito, Fernando Dangond, Suhayl Dhib-Jalbut

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The effect of pharmacologically relevant doses of interferon (IFN) β-1a on B-cell expression of B7.1 and B7.2 was investigated. Culture of peripheral blood mononuclear cells with IFN β-1a 100. IU/mL decreased B-cell expression of B7.1 and increased B7.2 expression. Interleukin-10 in B cells was significantly enhanced by IFN β-1a. Anti-CD3 and anti-CD28 monoclonal antibody-mediated T-cell proliferations were partially suppressed in the presence of B cells pretreated with IFN β-1a. These data suggest that IFN β-1a and B cells can interact to play a beneficial role in the treatment of multiple sclerosis.

Original language	English (US)
Pages (from-to)	27-31
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	258
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.02.010
State	Published - 2013

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Keywords

B cell
B7.2
Costimulation
Interferon beta
Multiple sclerosis
Peripheral blood mononuclear cell

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10.1016/j.jneuroim.2013.02.010

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title = "Effect of interferon beta-1a on B7.1 and B7.2 B-cell expression and its impact on T-cell proliferation",

abstract = "The effect of pharmacologically relevant doses of interferon (IFN) β-1a on B-cell expression of B7.1 and B7.2 was investigated. Culture of peripheral blood mononuclear cells with IFN β-1a 100. IU/mL decreased B-cell expression of B7.1 and increased B7.2 expression. Interleukin-10 in B cells was significantly enhanced by IFN β-1a. Anti-CD3 and anti-CD28 monoclonal antibody-mediated T-cell proliferations were partially suppressed in the presence of B cells pretreated with IFN β-1a. These data suggest that IFN β-1a and B cells can interact to play a beneficial role in the treatment of multiple sclerosis.",

keywords = "B cell, B7.2, Costimulation, Interferon beta, Multiple sclerosis, Peripheral blood mononuclear cell",

author = "Hui Huang and Kouichi Ito and Fernando Dangond and Suhayl Dhib-Jalbut",

note = "Funding Information: The authors thank Linda Kasten of Prometrika LLC, Boston, MA USA for statistical support of the study and Reza Sayeed, Esther Law, and Christopher Grantham from Caudex Medical Inc., NY, USA who provided writing and editorial assistance for the manuscript. Both Prometrika LLC and Caudex Medical Inc. were supported by EMD Serono, Inc. and Pfizer Inc.",

year = "2013",

doi = "10.1016/j.jneuroim.2013.02.010",

language = "English (US)",

volume = "258",

pages = "27--31",

journal = "Journal of Neuroimmunology",

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T1 - Effect of interferon beta-1a on B7.1 and B7.2 B-cell expression and its impact on T-cell proliferation

AU - Huang, Hui

AU - Ito, Kouichi

AU - Dangond, Fernando

AU - Dhib-Jalbut, Suhayl

N1 - Funding Information: The authors thank Linda Kasten of Prometrika LLC, Boston, MA USA for statistical support of the study and Reza Sayeed, Esther Law, and Christopher Grantham from Caudex Medical Inc., NY, USA who provided writing and editorial assistance for the manuscript. Both Prometrika LLC and Caudex Medical Inc. were supported by EMD Serono, Inc. and Pfizer Inc.

PY - 2013

Y1 - 2013

N2 - The effect of pharmacologically relevant doses of interferon (IFN) β-1a on B-cell expression of B7.1 and B7.2 was investigated. Culture of peripheral blood mononuclear cells with IFN β-1a 100. IU/mL decreased B-cell expression of B7.1 and increased B7.2 expression. Interleukin-10 in B cells was significantly enhanced by IFN β-1a. Anti-CD3 and anti-CD28 monoclonal antibody-mediated T-cell proliferations were partially suppressed in the presence of B cells pretreated with IFN β-1a. These data suggest that IFN β-1a and B cells can interact to play a beneficial role in the treatment of multiple sclerosis.

AB - The effect of pharmacologically relevant doses of interferon (IFN) β-1a on B-cell expression of B7.1 and B7.2 was investigated. Culture of peripheral blood mononuclear cells with IFN β-1a 100. IU/mL decreased B-cell expression of B7.1 and increased B7.2 expression. Interleukin-10 in B cells was significantly enhanced by IFN β-1a. Anti-CD3 and anti-CD28 monoclonal antibody-mediated T-cell proliferations were partially suppressed in the presence of B cells pretreated with IFN β-1a. These data suggest that IFN β-1a and B cells can interact to play a beneficial role in the treatment of multiple sclerosis.

KW - B cell

KW - B7.2

KW - Costimulation

KW - Interferon beta

KW - Multiple sclerosis

KW - Peripheral blood mononuclear cell

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Effect of interferon beta-1a on B7.1 and B7.2 B-cell expression and its impact on T-cell proliferation

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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