Effect of malnutrition on radiographic findings and mycobacterial burden in pulmonary tuberculosis

Kacie J. Hoyt, Sonali Sarkar, Laura White, Noyal Mariya Joseph, Padmini Salgame, Subitha Lakshminarayanan, Muthuraj Muthaiah, Saka Vinod Kumar, Jerrold J. Ellner, Gautam Roy, C. Robert Horsburgh, Natasha S. Hochberg

Research output: Contribution to journalArticle

Abstract

Background The relationship between malnutrition and tuberculosis (TB) severity is understudied. We investigated the effect of malnutrition on radiographic findings and mycobacterial burden. Methods Subjects included newly diagnosed, smear-positive, culture-confirmed, pulmonary TB cases enrolled in the Regional Prospective Observational Research for TB (RePORT) cohort. Multivariate regression models were used to evaluate the relationship at start of treatment between body mass index (BMI) and chest radiograph (CXR) findings of cavitation and percentage of lung affected and mycobacterial growth indicator tube (MGIT) time to positive (TTP). Severe malnutrition was defined as BMI<16 kg/m 2 , moderate malnutrition as 16–18.4kg/m 2 , and “normal”/overweight as 18.5 kg/m 2 . Results Of 173 TB cases with chest x-ray data, 131 (76%) were male. The median age was 45 years (range 16–82); 42 (24%) had severe malnutrition and 58 (34%) moderate malnutrition. Median percentage of lung affected was 32% (range 0–95), and 132 (76%) had cavitation. Individuals with severe malnutrition had, on average, 11.1% [95% CI: 4.0–13.3] more lung affected, compared to those with normal BMI, controlling for diabetes and cavitation. In multivariable analyses, cases with severe malnutrition had a 4.6-fold [95% CI, 1.5–14.1] increased odds of cavitation compared to those with normal BMI, controlling for smoking. Median MGIT TTP was 194.5 hours. Neither severe (aRR 0.99; 95% CI, 0.9–1.2) nor moderate (aRR 0.97; 95% CI, 0.8–1.1) malnutrition was associated with MGIT TTP. Conclusion We found that malnutrition was associated with increased extent of disease and cavitation on CXR. These findings may reflect the immunomodulatory effect of malnutrition on pulmonary pathology.

Original languageEnglish (US)
Article numbere0214011
JournalPloS one
Volume14
Issue number3
DOIs
StatePublished - Mar 2019

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Pulmonary Tuberculosis
Cavitation
tuberculosis
Malnutrition
malnutrition
lungs
body mass index
Body Mass Index
Lung
Tuberculosis
Pathology
Medical problems
chest
Thorax
Growth
X rays
diabetes
X-radiation
Smoking
X-Rays

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Hoyt, K. J., Sarkar, S., White, L., Joseph, N. M., Salgame, P., Lakshminarayanan, S., ... Hochberg, N. S. (2019). Effect of malnutrition on radiographic findings and mycobacterial burden in pulmonary tuberculosis. PloS one, 14(3), [e0214011]. https://doi.org/10.1371/journal.pone.0214011
Hoyt, Kacie J. ; Sarkar, Sonali ; White, Laura ; Joseph, Noyal Mariya ; Salgame, Padmini ; Lakshminarayanan, Subitha ; Muthaiah, Muthuraj ; Kumar, Saka Vinod ; Ellner, Jerrold J. ; Roy, Gautam ; Robert Horsburgh, C. ; Hochberg, Natasha S. / Effect of malnutrition on radiographic findings and mycobacterial burden in pulmonary tuberculosis. In: PloS one. 2019 ; Vol. 14, No. 3.
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abstract = "Background The relationship between malnutrition and tuberculosis (TB) severity is understudied. We investigated the effect of malnutrition on radiographic findings and mycobacterial burden. Methods Subjects included newly diagnosed, smear-positive, culture-confirmed, pulmonary TB cases enrolled in the Regional Prospective Observational Research for TB (RePORT) cohort. Multivariate regression models were used to evaluate the relationship at start of treatment between body mass index (BMI) and chest radiograph (CXR) findings of cavitation and percentage of lung affected and mycobacterial growth indicator tube (MGIT) time to positive (TTP). Severe malnutrition was defined as BMI<16 kg/m 2 , moderate malnutrition as 16–18.4kg/m 2 , and “normal”/overweight as 18.5 kg/m 2 . Results Of 173 TB cases with chest x-ray data, 131 (76{\%}) were male. The median age was 45 years (range 16–82); 42 (24{\%}) had severe malnutrition and 58 (34{\%}) moderate malnutrition. Median percentage of lung affected was 32{\%} (range 0–95), and 132 (76{\%}) had cavitation. Individuals with severe malnutrition had, on average, 11.1{\%} [95{\%} CI: 4.0–13.3] more lung affected, compared to those with normal BMI, controlling for diabetes and cavitation. In multivariable analyses, cases with severe malnutrition had a 4.6-fold [95{\%} CI, 1.5–14.1] increased odds of cavitation compared to those with normal BMI, controlling for smoking. Median MGIT TTP was 194.5 hours. Neither severe (aRR 0.99; 95{\%} CI, 0.9–1.2) nor moderate (aRR 0.97; 95{\%} CI, 0.8–1.1) malnutrition was associated with MGIT TTP. Conclusion We found that malnutrition was associated with increased extent of disease and cavitation on CXR. These findings may reflect the immunomodulatory effect of malnutrition on pulmonary pathology.",
author = "Hoyt, {Kacie J.} and Sonali Sarkar and Laura White and Joseph, {Noyal Mariya} and Padmini Salgame and Subitha Lakshminarayanan and Muthuraj Muthaiah and Kumar, {Saka Vinod} and Ellner, {Jerrold J.} and Gautam Roy and {Robert Horsburgh}, C. and Hochberg, {Natasha S.}",
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Hoyt, KJ, Sarkar, S, White, L, Joseph, NM, Salgame, P, Lakshminarayanan, S, Muthaiah, M, Kumar, SV, Ellner, JJ, Roy, G, Robert Horsburgh, C & Hochberg, NS 2019, 'Effect of malnutrition on radiographic findings and mycobacterial burden in pulmonary tuberculosis', PloS one, vol. 14, no. 3, e0214011. https://doi.org/10.1371/journal.pone.0214011

Effect of malnutrition on radiographic findings and mycobacterial burden in pulmonary tuberculosis. / Hoyt, Kacie J.; Sarkar, Sonali; White, Laura; Joseph, Noyal Mariya; Salgame, Padmini; Lakshminarayanan, Subitha; Muthaiah, Muthuraj; Kumar, Saka Vinod; Ellner, Jerrold J.; Roy, Gautam; Robert Horsburgh, C.; Hochberg, Natasha S.

In: PloS one, Vol. 14, No. 3, e0214011, 03.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of malnutrition on radiographic findings and mycobacterial burden in pulmonary tuberculosis

AU - Hoyt, Kacie J.

AU - Sarkar, Sonali

AU - White, Laura

AU - Joseph, Noyal Mariya

AU - Salgame, Padmini

AU - Lakshminarayanan, Subitha

AU - Muthaiah, Muthuraj

AU - Kumar, Saka Vinod

AU - Ellner, Jerrold J.

AU - Roy, Gautam

AU - Robert Horsburgh, C.

AU - Hochberg, Natasha S.

PY - 2019/3

Y1 - 2019/3

N2 - Background The relationship between malnutrition and tuberculosis (TB) severity is understudied. We investigated the effect of malnutrition on radiographic findings and mycobacterial burden. Methods Subjects included newly diagnosed, smear-positive, culture-confirmed, pulmonary TB cases enrolled in the Regional Prospective Observational Research for TB (RePORT) cohort. Multivariate regression models were used to evaluate the relationship at start of treatment between body mass index (BMI) and chest radiograph (CXR) findings of cavitation and percentage of lung affected and mycobacterial growth indicator tube (MGIT) time to positive (TTP). Severe malnutrition was defined as BMI<16 kg/m 2 , moderate malnutrition as 16–18.4kg/m 2 , and “normal”/overweight as 18.5 kg/m 2 . Results Of 173 TB cases with chest x-ray data, 131 (76%) were male. The median age was 45 years (range 16–82); 42 (24%) had severe malnutrition and 58 (34%) moderate malnutrition. Median percentage of lung affected was 32% (range 0–95), and 132 (76%) had cavitation. Individuals with severe malnutrition had, on average, 11.1% [95% CI: 4.0–13.3] more lung affected, compared to those with normal BMI, controlling for diabetes and cavitation. In multivariable analyses, cases with severe malnutrition had a 4.6-fold [95% CI, 1.5–14.1] increased odds of cavitation compared to those with normal BMI, controlling for smoking. Median MGIT TTP was 194.5 hours. Neither severe (aRR 0.99; 95% CI, 0.9–1.2) nor moderate (aRR 0.97; 95% CI, 0.8–1.1) malnutrition was associated with MGIT TTP. Conclusion We found that malnutrition was associated with increased extent of disease and cavitation on CXR. These findings may reflect the immunomodulatory effect of malnutrition on pulmonary pathology.

AB - Background The relationship between malnutrition and tuberculosis (TB) severity is understudied. We investigated the effect of malnutrition on radiographic findings and mycobacterial burden. Methods Subjects included newly diagnosed, smear-positive, culture-confirmed, pulmonary TB cases enrolled in the Regional Prospective Observational Research for TB (RePORT) cohort. Multivariate regression models were used to evaluate the relationship at start of treatment between body mass index (BMI) and chest radiograph (CXR) findings of cavitation and percentage of lung affected and mycobacterial growth indicator tube (MGIT) time to positive (TTP). Severe malnutrition was defined as BMI<16 kg/m 2 , moderate malnutrition as 16–18.4kg/m 2 , and “normal”/overweight as 18.5 kg/m 2 . Results Of 173 TB cases with chest x-ray data, 131 (76%) were male. The median age was 45 years (range 16–82); 42 (24%) had severe malnutrition and 58 (34%) moderate malnutrition. Median percentage of lung affected was 32% (range 0–95), and 132 (76%) had cavitation. Individuals with severe malnutrition had, on average, 11.1% [95% CI: 4.0–13.3] more lung affected, compared to those with normal BMI, controlling for diabetes and cavitation. In multivariable analyses, cases with severe malnutrition had a 4.6-fold [95% CI, 1.5–14.1] increased odds of cavitation compared to those with normal BMI, controlling for smoking. Median MGIT TTP was 194.5 hours. Neither severe (aRR 0.99; 95% CI, 0.9–1.2) nor moderate (aRR 0.97; 95% CI, 0.8–1.1) malnutrition was associated with MGIT TTP. Conclusion We found that malnutrition was associated with increased extent of disease and cavitation on CXR. These findings may reflect the immunomodulatory effect of malnutrition on pulmonary pathology.

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DO - 10.1371/journal.pone.0214011

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