TY - JOUR
T1 - Effect of nephrotomy on renal function and morphology in normal cats
AU - King, Michael D.
AU - Waldron, Don R.
AU - Barber, Don L.
AU - Larson, Martha M.
AU - Saunders, Geoffrey K.
AU - Troy, Gregory C.
AU - Zimmerman-Pope, Nancy
AU - Ward, Dan L.
PY - 2006/12
Y1 - 2006/12
N2 - Objective - To assess effects over 12 weeks of bisection nephrotomy on renal function, size, and morphology in cats. Study Design - Controlled, randomized, blinded experiment. Sample Population - Ten adult female cats. Methods - Glomerular filtration rate (GFR), determined by quantitative renal scintigraphy using 99mTechnetium-diethylenetriamine-pentaacetic acid , urinalysis, urine culture, and ultrasonographic measurement of renal size were performed preoperatively. Left or right nephrotomy (5 cats/group) was performed. Total and individual kidney GFRs were determined at 2, 28, and 84 days, ultrasonographic measurements at 28 and 86 days, and ultrasound-guided biopsy at 86 days. Results - No significant differences in mean GFR and kidney size of operated versus unoperated kidneys were observed. Individual GFR and renal size of all except 1 cat remained within normal limits. Two cats had evidence of transient ureteral obstruction in the immediate postoperative period. No significant, generalized histologic abnormalities were observed. Conclusions - Bisection nephrotomy in normal cats does not adversely affect renal function or morphology during the initial 12 weeks. Clinical Relevance - Bisection nephrotomy can be safely performed in normal feline kidneys without causing a significant deleterious effect on renal function. Studies in cats with pre-existing renal insufficiency are needed to ensure adverse effects would not occur in clinical cases where this surgical procedure is warranted.
AB - Objective - To assess effects over 12 weeks of bisection nephrotomy on renal function, size, and morphology in cats. Study Design - Controlled, randomized, blinded experiment. Sample Population - Ten adult female cats. Methods - Glomerular filtration rate (GFR), determined by quantitative renal scintigraphy using 99mTechnetium-diethylenetriamine-pentaacetic acid , urinalysis, urine culture, and ultrasonographic measurement of renal size were performed preoperatively. Left or right nephrotomy (5 cats/group) was performed. Total and individual kidney GFRs were determined at 2, 28, and 84 days, ultrasonographic measurements at 28 and 86 days, and ultrasound-guided biopsy at 86 days. Results - No significant differences in mean GFR and kidney size of operated versus unoperated kidneys were observed. Individual GFR and renal size of all except 1 cat remained within normal limits. Two cats had evidence of transient ureteral obstruction in the immediate postoperative period. No significant, generalized histologic abnormalities were observed. Conclusions - Bisection nephrotomy in normal cats does not adversely affect renal function or morphology during the initial 12 weeks. Clinical Relevance - Bisection nephrotomy can be safely performed in normal feline kidneys without causing a significant deleterious effect on renal function. Studies in cats with pre-existing renal insufficiency are needed to ensure adverse effects would not occur in clinical cases where this surgical procedure is warranted.
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U2 - 10.1111/j.1532-950X.2006.00219.x
DO - 10.1111/j.1532-950X.2006.00219.x
M3 - Article
C2 - 17187637
AN - SCOPUS:33845435971
VL - 35
SP - 749
EP - 758
JO - Veterinary Surgery
JF - Veterinary Surgery
SN - 0161-3499
IS - 8
ER -