Objective - To assess effects over 12 weeks of bisection nephrotomy on renal function, size, and morphology in cats. Study Design - Controlled, randomized, blinded experiment. Sample Population - Ten adult female cats. Methods - Glomerular filtration rate (GFR), determined by quantitative renal scintigraphy using 99mTechnetium-diethylenetriamine-pentaacetic acid , urinalysis, urine culture, and ultrasonographic measurement of renal size were performed preoperatively. Left or right nephrotomy (5 cats/group) was performed. Total and individual kidney GFRs were determined at 2, 28, and 84 days, ultrasonographic measurements at 28 and 86 days, and ultrasound-guided biopsy at 86 days. Results - No significant differences in mean GFR and kidney size of operated versus unoperated kidneys were observed. Individual GFR and renal size of all except 1 cat remained within normal limits. Two cats had evidence of transient ureteral obstruction in the immediate postoperative period. No significant, generalized histologic abnormalities were observed. Conclusions - Bisection nephrotomy in normal cats does not adversely affect renal function or morphology during the initial 12 weeks. Clinical Relevance - Bisection nephrotomy can be safely performed in normal feline kidneys without causing a significant deleterious effect on renal function. Studies in cats with pre-existing renal insufficiency are needed to ensure adverse effects would not occur in clinical cases where this surgical procedure is warranted.
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