Effect of ouabain on O2 supply/demand in normal and ischemic heart

Ellen Buchweitz; J. Bottalico; H. R. Weiss

doi:10.1007/BF01907946

Effect of ouabain on O₂ supply/demand in normal and ischemic heart

Ellen Buchweitz, J. Bottalico, H. R. Weiss

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The effect of ouabain (15 μg/kg) on subepicardial and subendocardial blood flow, oxygenation, and small-vessel blood content was studied in anesthetized open-chest rabbits with hearts subjected to acute coronary occlusion. 10 minutes after occlusion, blood flow was 48% lower than in the control region. Ouabain lowered blood flow significantly in the non-occluded region and insignificantly in the occluded area. Small-vessel blood content, a measure of open capillary density, was unaffected by occlusion or ouabain. After occlusion, relative tissue PO₂ fell to a greater extent in the affected subendocardium than the affected subepicardium. Ouabain, therefore, appears to be well tolerated in both the control and ischemic regions in terms of oxygen supply and consumption.

Original language	English (US)
Pages (from-to)	552-561
Number of pages	10
Journal	Basic research in cardiology
Volume	77
Issue number	5
DOIs	https://doi.org/10.1007/BF01907946
State	Published - Sep 1982

All Science Journal Classification (ASJC) codes

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

Keywords

coronary blood flow
open capillary densit tissue oxygenation
ouabain

Access to Document

10.1007/BF01907946

Cite this

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title = "Effect of ouabain on O2 supply/demand in normal and ischemic heart",

abstract = "The effect of ouabain (15 μg/kg) on subepicardial and subendocardial blood flow, oxygenation, and small-vessel blood content was studied in anesthetized open-chest rabbits with hearts subjected to acute coronary occlusion. 10 minutes after occlusion, blood flow was 48% lower than in the control region. Ouabain lowered blood flow significantly in the non-occluded region and insignificantly in the occluded area. Small-vessel blood content, a measure of open capillary density, was unaffected by occlusion or ouabain. After occlusion, relative tissue PO2 fell to a greater extent in the affected subendocardium than the affected subepicardium. Ouabain, therefore, appears to be well tolerated in both the control and ischemic regions in terms of oxygen supply and consumption.",

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N2 - The effect of ouabain (15 μg/kg) on subepicardial and subendocardial blood flow, oxygenation, and small-vessel blood content was studied in anesthetized open-chest rabbits with hearts subjected to acute coronary occlusion. 10 minutes after occlusion, blood flow was 48% lower than in the control region. Ouabain lowered blood flow significantly in the non-occluded region and insignificantly in the occluded area. Small-vessel blood content, a measure of open capillary density, was unaffected by occlusion or ouabain. After occlusion, relative tissue PO2 fell to a greater extent in the affected subendocardium than the affected subepicardium. Ouabain, therefore, appears to be well tolerated in both the control and ischemic regions in terms of oxygen supply and consumption.

AB - The effect of ouabain (15 μg/kg) on subepicardial and subendocardial blood flow, oxygenation, and small-vessel blood content was studied in anesthetized open-chest rabbits with hearts subjected to acute coronary occlusion. 10 minutes after occlusion, blood flow was 48% lower than in the control region. Ouabain lowered blood flow significantly in the non-occluded region and insignificantly in the occluded area. Small-vessel blood content, a measure of open capillary density, was unaffected by occlusion or ouabain. After occlusion, relative tissue PO2 fell to a greater extent in the affected subendocardium than the affected subepicardium. Ouabain, therefore, appears to be well tolerated in both the control and ischemic regions in terms of oxygen supply and consumption.

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