Effect of short- and long-term diabetes on carnitine and myo-inositol in rats

A. S. Reddi, G. N. Jyothirmayi, B. DeAngelis, O. Frank, H. Baker

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


1. 1. The effect of short- (2 wk) and long-term (20 wk) streptozotocin diabetes was studied on urine, blood, liver, heart, brain, skeletal muscle, pancreas and kidney concentrations of acid-soluble carnitine and free myo-inositol. 2. 2. Short-term diabetic rats excreted significantly higher concentrations of carnitine as well as myo-inositol than normal rats. Blood carnitine and myo-inositol were not different between normal and diabetic rats. Diabetes caused a decrease in liver, brain and pancreatic carnitine, but not in heart, skeletal muscle and kidney. Myo-inositol concentration was decreased in liver, heart and kidney but not in brain, pancreas and skeletal muscle. 3. 3. Long-term diabetic rats had higher urinary excretions of both carnitine and myo-inositol. Blood carnitine did not change; however, myo-inositol was higher in diabetic than in normal rats. Diabetes caused a significant increase in liver and a decrease in heart, brain, skeletal muscle and pancreatic content of carnitine; no difference in kidney carnitine was noted. Myo-inositol content was elevated only in liver of diabetic rats. 4. 4. We suggest that carnitine and myo-inositol concentrations are influenced both by short- and long-term diabetes through changes in tissue metabolism.

Original languageEnglish (US)
Pages (from-to)39-42
Number of pages4
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Issue number1
StatePublished - 1991

All Science Journal Classification (ASJC) codes

  • Physiology


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