Effect of tissue factor on plasma and packed RBC clotting parameters

Darshana R. Patel, John Davidson, David Kristol, Charles R. Spillert

Research output: Contribution to conferencePaperpeer-review

Abstract

Tissue factor (TF) is a transmembrane glycoprotein and the main triggering element for blood coagulation. Expression of TF on the cell surfaces and its appearance as a soluble molecule are characteristic features of acute and chronic inflammation in conditions such as arteriosclerosis leading to stroke and myocardial infection. A study was performed on human citrated whole blood, by separating plasma from the red blood cells. Ten microlitres of 25% Tissue Factor (TF) was added to both the plasma and packed red blood cells (RBC's), and the clotting time, rate of clot formation and the maximum strength of the clot determined. TF bearing samples clotted more rapidly and had greater clot strength when compared to that of control aliquots.

Original languageEnglish (US)
Pages251-252
Number of pages2
StatePublished - 2004
EventProceedings of the IEEE 30th Annual Northeast Bioengineering Conference - Springfield, MA, United States
Duration: Apr 17 2004Apr 18 2004

Other

OtherProceedings of the IEEE 30th Annual Northeast Bioengineering Conference
Country/TerritoryUnited States
CitySpringfield, MA
Period4/17/044/18/04

All Science Journal Classification (ASJC) codes

  • Bioengineering

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