Effect of tyrosine-derived triblock copolymer compositions on nanosphere self-assembly and drug delivery

Larisa Sheihet, Karolina Piotrowska, Robert A. Dubin, Joachim Kohn, David Devore

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

We have obtained structure - activity relations for nanosphere drug delivery as a function of the chemical properties of a tunable family of self-assembling triblock copolymers. These block copolymers are synthesized with hydrophobic oligomers of a desaminotyrosyl tyrosine ester and diacid and hydrophilic poly(ethylene glycol). We have calculated the thermodynamic interaction parameters for the copolymers with anti-tumor drugs to provide an understanding of the drug binding by the nanospheres. We find that there is an optimum ester chain length, C8, for nanospheres in terms of their drug loading capacities. The nanospheres release the drugs under dialysis conditions, with release rates strongly influenced by solution pH. The nanospheres, which are themselves non-cytotoxic, deliver the hydrophobic drugs very effectively to tumor cells as measured by cell killing activity in vitro and thus offer the potential for effective parentarel in vivo delivery of many hydrophobic therapeutic agents.

Original languageEnglish (US)
Pages (from-to)998-1003
Number of pages6
JournalBiomacromolecules
Volume8
Issue number3
DOIs
StatePublished - Mar 2007

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Effect of tyrosine-derived triblock copolymer compositions on nanosphere self-assembly and drug delivery'. Together they form a unique fingerprint.

Cite this