Effect of waveshape on iontophoretic drug delivery

C. Zakzewski, John Li, D. Amory, E. Kalatzis-Manolakis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Iontophoresis is a form of transdermal delivery which forces poorly absorbed ionic drugs through the skin using a current to enhance penetration. To study the effect of waveshape on iontophoretic efficacy, a device was designed to synthesize several constant current waveforms including DC and pulsed DC, and two novel iontophoretic waveforms - trapezoidal and biphasic pulsed DC. Each waveform was used to deliver an antihypertensive drug transdermally to acutely induced hypertensive rabbits.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual Conference on Engineering in Medicine and Biology
EditorsAndrew Y.J. Szeto, Rangaraj M. Rangayyan
PublisherPubl by IEEE
Number of pages1
Volume15
Editionpt 2
ISBN (Print)0780313771
StatePublished - Dec 1 1993
Externally publishedYes
EventProceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3) - San Diego, CA, USA
Duration: Oct 28 1993Oct 31 1993

Other

OtherProceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3)
CitySan Diego, CA, USA
Period10/28/9310/31/93

Fingerprint

Ionic drugs
Drug delivery
Antihypertensive Agents
Skin
Iontophoresis

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Zakzewski, C., Li, J., Amory, D., & Kalatzis-Manolakis, E. (1993). Effect of waveshape on iontophoretic drug delivery. In A. Y. J. Szeto, & R. M. Rangayyan (Eds.), Proceedings of the Annual Conference on Engineering in Medicine and Biology (pt 2 ed., Vol. 15). Publ by IEEE.
Zakzewski, C. ; Li, John ; Amory, D. ; Kalatzis-Manolakis, E. / Effect of waveshape on iontophoretic drug delivery. Proceedings of the Annual Conference on Engineering in Medicine and Biology. editor / Andrew Y.J. Szeto ; Rangaraj M. Rangayyan. Vol. 15 pt 2. ed. Publ by IEEE, 1993.
@inproceedings{468bbc131e5546d8908f9619c48cf74c,
title = "Effect of waveshape on iontophoretic drug delivery",
abstract = "Iontophoresis is a form of transdermal delivery which forces poorly absorbed ionic drugs through the skin using a current to enhance penetration. To study the effect of waveshape on iontophoretic efficacy, a device was designed to synthesize several constant current waveforms including DC and pulsed DC, and two novel iontophoretic waveforms - trapezoidal and biphasic pulsed DC. Each waveform was used to deliver an antihypertensive drug transdermally to acutely induced hypertensive rabbits.",
author = "C. Zakzewski and John Li and D. Amory and E. Kalatzis-Manolakis",
year = "1993",
month = "12",
day = "1",
language = "English (US)",
isbn = "0780313771",
volume = "15",
editor = "Szeto, {Andrew Y.J.} and Rangayyan, {Rangaraj M.}",
booktitle = "Proceedings of the Annual Conference on Engineering in Medicine and Biology",
publisher = "Publ by IEEE",
edition = "pt 2",

}

Zakzewski, C, Li, J, Amory, D & Kalatzis-Manolakis, E 1993, Effect of waveshape on iontophoretic drug delivery. in AYJ Szeto & RM Rangayyan (eds), Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2 edn, vol. 15, Publ by IEEE, Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3), San Diego, CA, USA, 10/28/93.

Effect of waveshape on iontophoretic drug delivery. / Zakzewski, C.; Li, John; Amory, D.; Kalatzis-Manolakis, E.

Proceedings of the Annual Conference on Engineering in Medicine and Biology. ed. / Andrew Y.J. Szeto; Rangaraj M. Rangayyan. Vol. 15 pt 2. ed. Publ by IEEE, 1993.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Effect of waveshape on iontophoretic drug delivery

AU - Zakzewski, C.

AU - Li, John

AU - Amory, D.

AU - Kalatzis-Manolakis, E.

PY - 1993/12/1

Y1 - 1993/12/1

N2 - Iontophoresis is a form of transdermal delivery which forces poorly absorbed ionic drugs through the skin using a current to enhance penetration. To study the effect of waveshape on iontophoretic efficacy, a device was designed to synthesize several constant current waveforms including DC and pulsed DC, and two novel iontophoretic waveforms - trapezoidal and biphasic pulsed DC. Each waveform was used to deliver an antihypertensive drug transdermally to acutely induced hypertensive rabbits.

AB - Iontophoresis is a form of transdermal delivery which forces poorly absorbed ionic drugs through the skin using a current to enhance penetration. To study the effect of waveshape on iontophoretic efficacy, a device was designed to synthesize several constant current waveforms including DC and pulsed DC, and two novel iontophoretic waveforms - trapezoidal and biphasic pulsed DC. Each waveform was used to deliver an antihypertensive drug transdermally to acutely induced hypertensive rabbits.

UR - http://www.scopus.com/inward/record.url?scp=0027832148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027832148&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0027832148

SN - 0780313771

VL - 15

BT - Proceedings of the Annual Conference on Engineering in Medicine and Biology

A2 - Szeto, Andrew Y.J.

A2 - Rangayyan, Rangaraj M.

PB - Publ by IEEE

ER -

Zakzewski C, Li J, Amory D, Kalatzis-Manolakis E. Effect of waveshape on iontophoretic drug delivery. In Szeto AYJ, Rangayyan RM, editors, Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2 ed. Vol. 15. Publ by IEEE. 1993