Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus peel flavonoids

Ching Shu Lai, Shiming Li, Cheng Bin Liu, Yutaka Miyauchi, Michiko Suzawa, Chi Tang Ho, Min Hsiung Pan

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Citrus peel or its extract has been reported to exhibit a broad spectrum of biological activity. Herein, we report the first investigation of inhibitory effects of a formulated product from citrus peel extract, gold lotion (GL), on azoxymethane-induced colonic tumorigenesis. We have demonstrated that oral feeding of GL decreased the number of aberrant crypt foci (ACF), particularly large size of ACF in colonic tissues of mice. Both gene and protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were suppressed by GL treatment. The in vivo data have revealed for the first time that the citrus peel extract-GL-is an effective antitumor agent mechanistically downregulating the protein levels of iNOS, COX-2, ornithine decarboxylase, vascular endothelial growth factor, and matrix metallopeptidase 9 in colonic tissues of mice, suggesting that GL is a novel functional natural product capable of preventing inflammation-associated colon tumorigenesis.

Original languageEnglish (US)
Pages (from-to)551-555
Number of pages5
JournalMolecular Nutrition and Food Research
Volume57
Issue number3
DOIs
StatePublished - Mar 2013

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science

Keywords

  • Aberrant crypt foci
  • Azoxymethane
  • Citrus peel
  • Gold lotion

Fingerprint Dive into the research topics of 'Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus peel flavonoids'. Together they form a unique fingerprint.

Cite this