Effects of blender rotational speed and discharge on the homogeneity of cohesive and free-flowing mixtures

O. S. Sudah, D. Coffin-Beach, Fernando Muzzio

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

The roles of blender rotational speed and blender discharge on the homogeneity of free-flowing art sand and of a cohesive placebo formulation were investigated in the tote blender. For three practical operating speeds, 6, 10, and 14 RPM, spanning the entire range of commercial equipment, the homogeneity of the free-flowing mixture was independent of rotational speed and blender size. On the other hand, the homogeneity of the cohesive pharmaceutical powder mixture was dependent on vessel rotational speed in a complex fashion, with 10 RPM producing a better final mixture than either 5 or 15 RPM. The homogeneity of the free-flowing sand mixture was preserved when discharged into a vertical bin, while the homogeneity of the fine pharmaceutical powder mixture significantly improved after discharge from the tote blender.

Original languageEnglish (US)
Pages (from-to)57-68
Number of pages12
JournalInternational Journal of Pharmaceutics
Volume247
Issue number1-2
DOIs
StatePublished - Oct 24 2002

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Bin
  • Discharge
  • Powder mixing
  • Sampling
  • Tote blender
  • Tumbling speed

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