Effects of chronic heart failure on the inotropic response of the right ventricle of the conscious dog to a cardiac glycoside and to tachycardia

S. F. Vatner, E. Braunwald

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effects of ouabain, 20 μg/kg, and elevation of cardiac rate from 90 to 240 beats/min (Bowditch phenomenon) were examined on right ventricular (RV) segment length (SL), pressure (P), velocity of shortening (V), dP/dt, and dP/dt/P in conscious dogs before and after chronic right heart failure was induced by tricuspid avulsion and pulmonary stenosis, or by pulmonary stenosis alone. Chronic pulmonary stenosis and tricuspid regurgitation increased RV systolic P from 25 ± 3 to 59 ± 7 mm Hg, end diastolic P from 3 ± 1 to 16 ± 2 mm Hg and reduced dP/dt/P from 48 ± 6 to 24 ± 4 sec -1 and V from 26 ± 3 to 15 ± 3 mm/sec. Both ouabain and tachycardia exerted relatively minor inotropic effects in normal healthy, conscious dogs; dP/dt/P and V rose by 18 ± 2 and 17 ± 2% with ouabain, and by 15 ± 3 and 16 ± 3% with tachycardia. When the tachycardia induced reductions in end diastolic SL, were prevented by saline infusion, the increases in dP/dt/P and V were 19 ± 3% and 21 ± 3%. After chronic heart failure had been induced, the positive inotropic increases, with ouabain and tachycardia expressed on an absolute or relative basis, were significantly greater than had occurred in the dogs prior to heart failure; dP/dt/P and V rose by 47 ± 5 and 48 ± 6% with ouabain and by 41 ± 4% and 51 ± 3% with tachycardia. Thus, cardiac glycosides and the Bowditch phenomenon exert relatively minor positive inotropic responses in the nonfailing heart of the conscious dog when compared with the responses to these stimuli in the failing heart.

Original languageEnglish (US)
Pages (from-to)728-734
Number of pages7
JournalCirculation
Volume50
Issue number4
DOIs
StatePublished - Jan 1 1974

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Cardiac Glycosides
Ouabain
Tachycardia
Heart Ventricles
Heart Failure
Pulmonary Valve Stenosis
Dogs
Pulmonary Valve Insufficiency
Tricuspid Valve Insufficiency
Pressure

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

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title = "Effects of chronic heart failure on the inotropic response of the right ventricle of the conscious dog to a cardiac glycoside and to tachycardia",
abstract = "The effects of ouabain, 20 μg/kg, and elevation of cardiac rate from 90 to 240 beats/min (Bowditch phenomenon) were examined on right ventricular (RV) segment length (SL), pressure (P), velocity of shortening (V), dP/dt, and dP/dt/P in conscious dogs before and after chronic right heart failure was induced by tricuspid avulsion and pulmonary stenosis, or by pulmonary stenosis alone. Chronic pulmonary stenosis and tricuspid regurgitation increased RV systolic P from 25 ± 3 to 59 ± 7 mm Hg, end diastolic P from 3 ± 1 to 16 ± 2 mm Hg and reduced dP/dt/P from 48 ± 6 to 24 ± 4 sec -1 and V from 26 ± 3 to 15 ± 3 mm/sec. Both ouabain and tachycardia exerted relatively minor inotropic effects in normal healthy, conscious dogs; dP/dt/P and V rose by 18 ± 2 and 17 ± 2{\%} with ouabain, and by 15 ± 3 and 16 ± 3{\%} with tachycardia. When the tachycardia induced reductions in end diastolic SL, were prevented by saline infusion, the increases in dP/dt/P and V were 19 ± 3{\%} and 21 ± 3{\%}. After chronic heart failure had been induced, the positive inotropic increases, with ouabain and tachycardia expressed on an absolute or relative basis, were significantly greater than had occurred in the dogs prior to heart failure; dP/dt/P and V rose by 47 ± 5 and 48 ± 6{\%} with ouabain and by 41 ± 4{\%} and 51 ± 3{\%} with tachycardia. Thus, cardiac glycosides and the Bowditch phenomenon exert relatively minor positive inotropic responses in the nonfailing heart of the conscious dog when compared with the responses to these stimuli in the failing heart.",
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Effects of chronic heart failure on the inotropic response of the right ventricle of the conscious dog to a cardiac glycoside and to tachycardia. / Vatner, S. F.; Braunwald, E.

In: Circulation, Vol. 50, No. 4, 01.01.1974, p. 728-734.

Research output: Contribution to journalArticle

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