Effects of cyanate, thiocyanate, and amygdalin on metabolite uptake in normal and neoplastic tissues of the rat

Thiocyanate was found to resemble cyanate In Its Inhibitory effects on [³H]thymidine Incorporation and the uptake of [³²P]phosphate and [³H]amino acids In transplanted tumors of the BUF rat. The capacity to inhibit metabolite uptake In hepatomas and a colon tumor under conditions In which uptake was unchanged or Increased In host liver was concluded to be a common feature of the action of cyanate and thiocyanate. Inhibition of [³²P]phosphate uptake and [³H]thymidlne Incorporation Into DNA of tumors was also observed after treatment of rats with amygdalin. With this drug, however, the action on tumors and livers of host rats was similar.