TY - JOUR
T1 - Effects of dietary components on gi absorption of acetaminophen tablets in man
AU - Jaffe, James M.
AU - Colaizzi, John L.
AU - Barry, Herbert
N1 - Funding Information:
Received January 15, 1971, from the American Dental Association, Research Institute, Chicago, ZL 60611 Accepted for publication June 18, 1971. Supported in part by N.I.D.R. Training Grant DE 171 and by the American Dental Association. The authors are indebted to Miss Judy Osborn and Mr. John Edwards for technical assistance; to Dr. Anthony J. Glazko, Parke, Davis and Co., for supplying the hydantoin derivatives used in these studies; and to Dr. Gerard Casey, American Dental Association, for drawing human blood samples. * To whom reprint requests should be addressed. t Present address: School of Pharmacy, University of Wisconsin, Madison, W153706 3 Present address: College of Pharmacy, University of Florida, Gainesville, FL 32603
PY - 1971/11
Y1 - 1971/11
N2 - Various high carbohydrate, high protein, and high lipid test meals were administered concurrently with acetaminophen tablets to human subjects to study the effects of foods on GI absorption of this drug. Balanced test meals and a fasting condition were also employed. An indication of the rate and extent of drug absorption was obtained by measuring urinary excretion at 1.5‐hr. intervals over a 9‐hr. period. The initial rate of excretion of acetaminophen and its metabolites was significantly reduced with a majority of the carbohydrate test meals. High protein, high lipid, or balanced meals appeared to have no statistically significant effect, while the fasting condition showed only a trend toward initially higher excretion values. The cumulative amounts of total acetaminophen and metabolites excreted in the urine at the end of 9 hr. showed little difference among test meals. The apparent inhibition of acetaminophen absorption by carbohydrate test meals could be partially attributed to an interaction with pectin in some cases.
AB - Various high carbohydrate, high protein, and high lipid test meals were administered concurrently with acetaminophen tablets to human subjects to study the effects of foods on GI absorption of this drug. Balanced test meals and a fasting condition were also employed. An indication of the rate and extent of drug absorption was obtained by measuring urinary excretion at 1.5‐hr. intervals over a 9‐hr. period. The initial rate of excretion of acetaminophen and its metabolites was significantly reduced with a majority of the carbohydrate test meals. High protein, high lipid, or balanced meals appeared to have no statistically significant effect, while the fasting condition showed only a trend toward initially higher excretion values. The cumulative amounts of total acetaminophen and metabolites excreted in the urine at the end of 9 hr. showed little difference among test meals. The apparent inhibition of acetaminophen absorption by carbohydrate test meals could be partially attributed to an interaction with pectin in some cases.
KW - Absorption kinetics, GI–acetaminophen tablets, effect of foods, man
KW - Acetaminophen tablets—effect of foods on GI absorption, man
KW - Dietary considerations—GI absorption of acetaminophen tablets in man
KW - Foods‐effect of high carbohydrate, high protein, high lipid test meals on GI absorption of acetaminophen tablets, man
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U2 - 10.1002/jps.2600601111
DO - 10.1002/jps.2600601111
M3 - Article
C2 - 5133912
AN - SCOPUS:0015146669
SN - 0022-3549
VL - 60
SP - 1646
EP - 1650
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 11
ER -