Effects of electrical stimulation of the medial aspect of the prefrontal cortex upon attack behavior in cats

Allan Siegel; Henry Edinger; Henry Lowenthal

doi:10.1016/0006-8993(74)90061-4

Effects of electrical stimulation of the medial aspect of the prefrontal cortex upon attack behavior in cats

Allan Siegel, Henry Edinger, Henry Lowenthal

NJMS-Pharmacology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

An experiment was performed in order to determine the role of the medial aspect of the prefrontal cortex in the regulation of aggressive behavior in the cat. The results of this study demonstrated that electrical stimulation of the medial prefrontal cortex suppressed quiet biting attack, affective display elicited from electrical stimulation of the hypothalamus, and spontaneously elicited quiet biting attack. In contrast, stimulation of the prefrontal cortex did not measurably affect flight responses elicited from stimulation of the hypothalamus. The results of anatomical studies in the cat have suggested that inhibition of aggression is mediated indirectly upon the hypothalamus via the mediodorsal thalamic nucleus.

Original language	English (US)
Pages (from-to)	467-479
Number of pages	13
Journal	Brain research
Volume	66
Issue number	3
DOIs	https://doi.org/10.1016/0006-8993(74)90061-4
State	Published - Feb 8 1974

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Effects of electrical stimulation of the medial aspect of the prefrontal cortex upon attack behavior in cats",

abstract = "An experiment was performed in order to determine the role of the medial aspect of the prefrontal cortex in the regulation of aggressive behavior in the cat. The results of this study demonstrated that electrical stimulation of the medial prefrontal cortex suppressed quiet biting attack, affective display elicited from electrical stimulation of the hypothalamus, and spontaneously elicited quiet biting attack. In contrast, stimulation of the prefrontal cortex did not measurably affect flight responses elicited from stimulation of the hypothalamus. The results of anatomical studies in the cat have suggested that inhibition of aggression is mediated indirectly upon the hypothalamus via the mediodorsal thalamic nucleus.",

author = "Allan Siegel and Henry Edinger and Henry Lowenthal",

note = "Funding Information: The authors wish to thank Miss Ann Yoanides for her skillful histological preparation of the slides and Dr. William Zeman for his expert assistance in the care and preparation of the animals. This research was supported by National Institutes of Health, Grant NS 07941-03 from the Council of Neurological Diseases and Stroke and by the Benevolent Foundation of Scottish Rite Freemasonry, Northern Jurisdiction, U.S.A. Henry Lowenthal was a medical student Summer Fellow who was supported by funds from the Fund for the Advancement of Biomedical Research of the College of Medicine and Dentistry of New Jersey, New Jersey Medical School.",

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AU - Lowenthal, Henry

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