Effects of endurance and endurance-strength exercise on biochemical parameters of liver function in women with abdominal obesity

Damian Skrypnik, Marzena Ratajczak, Joanna Karolkiewicz, Edyta Madry, Danuta Pupek-Musialik, Rita Hansdorfer-Korzon, Jarosław Walkowiak, Hieronim Jakubowski, Paweł Bogdański

Research output: Contribution to journalArticle

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Abstract

Introduction: Obesity is a risk factor of nonalcoholic fatty liver disease. Although the standard therapy for obesity involves physical exercise, well-planned studies of the changes in liver function in response to different exercise intensities in obese subjects are scarce. The aim of the present study was to examine a question of how does exercise mode affect the liver function. Material and methods: 44 women with abdominal obesity were randomized into two exercise groups: endurance (group A) and endurance-strength (group B). Women in each group exercised for 60 min 3 times/week for a 3-month period. Markers of liver function: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltranspeptidase (GGT), alkaline phosphatase (ALP) activities, and bilirubin levels were quantified. Results: We found significant differences in ALT (p < 0.01) and AST (p < 0.05) activities between group A and B after training exercise. Blood ALT and AST tended to decrease in group B, increase in group A. Significant reduction in serum GGT level after exercise in both groups was observed (p < 0.001, group A; p < 0.01, group B). Neither endurance nor endurance-strength exercise led to changes in serum ALP activity and total or direct bilirubin level. However, endurance-strength training resulted in significant decreases in serum indirect bilirubin (p < 0.05). Strong positive correlations between serum indirect bilirubin and body mass (r = 0.615; p = 0.0085) and BMI (r = 0.576; p = 0.0154) were found after endurance-strength exercise (group B). Conclusion: The mode of exercise does matter: endurance-strength exercise led to a greater improvement, compared to endurance exercise, in the liver function in women with abdominal obesity.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalBiomedicine and Pharmacotherapy
Volume80
DOIs
StatePublished - May 1 2016

Fingerprint

Abdominal Obesity
Exercise
Liver
Bilirubin
Aspartate Aminotransferases
Alanine Transaminase
Serum
Alkaline Phosphatase
Obesity
Resistance Training

All Science Journal Classification (ASJC) codes

  • Pharmacology

Keywords

  • Liver function
  • Obesity
  • Physical exercise

Cite this

Skrypnik, D., Ratajczak, M., Karolkiewicz, J., Madry, E., Pupek-Musialik, D., Hansdorfer-Korzon, R., ... Bogdański, P. (2016). Effects of endurance and endurance-strength exercise on biochemical parameters of liver function in women with abdominal obesity. Biomedicine and Pharmacotherapy, 80, 1-7. https://doi.org/10.1016/j.biopha.2016.02.017
Skrypnik, Damian ; Ratajczak, Marzena ; Karolkiewicz, Joanna ; Madry, Edyta ; Pupek-Musialik, Danuta ; Hansdorfer-Korzon, Rita ; Walkowiak, Jarosław ; Jakubowski, Hieronim ; Bogdański, Paweł. / Effects of endurance and endurance-strength exercise on biochemical parameters of liver function in women with abdominal obesity. In: Biomedicine and Pharmacotherapy. 2016 ; Vol. 80. pp. 1-7.
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Skrypnik, D, Ratajczak, M, Karolkiewicz, J, Madry, E, Pupek-Musialik, D, Hansdorfer-Korzon, R, Walkowiak, J, Jakubowski, H & Bogdański, P 2016, 'Effects of endurance and endurance-strength exercise on biochemical parameters of liver function in women with abdominal obesity', Biomedicine and Pharmacotherapy, vol. 80, pp. 1-7. https://doi.org/10.1016/j.biopha.2016.02.017

Effects of endurance and endurance-strength exercise on biochemical parameters of liver function in women with abdominal obesity. / Skrypnik, Damian; Ratajczak, Marzena; Karolkiewicz, Joanna; Madry, Edyta; Pupek-Musialik, Danuta; Hansdorfer-Korzon, Rita; Walkowiak, Jarosław; Jakubowski, Hieronim; Bogdański, Paweł.

In: Biomedicine and Pharmacotherapy, Vol. 80, 01.05.2016, p. 1-7.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of endurance and endurance-strength exercise on biochemical parameters of liver function in women with abdominal obesity

AU - Skrypnik, Damian

AU - Ratajczak, Marzena

AU - Karolkiewicz, Joanna

AU - Madry, Edyta

AU - Pupek-Musialik, Danuta

AU - Hansdorfer-Korzon, Rita

AU - Walkowiak, Jarosław

AU - Jakubowski, Hieronim

AU - Bogdański, Paweł

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Introduction: Obesity is a risk factor of nonalcoholic fatty liver disease. Although the standard therapy for obesity involves physical exercise, well-planned studies of the changes in liver function in response to different exercise intensities in obese subjects are scarce. The aim of the present study was to examine a question of how does exercise mode affect the liver function. Material and methods: 44 women with abdominal obesity were randomized into two exercise groups: endurance (group A) and endurance-strength (group B). Women in each group exercised for 60 min 3 times/week for a 3-month period. Markers of liver function: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltranspeptidase (GGT), alkaline phosphatase (ALP) activities, and bilirubin levels were quantified. Results: We found significant differences in ALT (p < 0.01) and AST (p < 0.05) activities between group A and B after training exercise. Blood ALT and AST tended to decrease in group B, increase in group A. Significant reduction in serum GGT level after exercise in both groups was observed (p < 0.001, group A; p < 0.01, group B). Neither endurance nor endurance-strength exercise led to changes in serum ALP activity and total or direct bilirubin level. However, endurance-strength training resulted in significant decreases in serum indirect bilirubin (p < 0.05). Strong positive correlations between serum indirect bilirubin and body mass (r = 0.615; p = 0.0085) and BMI (r = 0.576; p = 0.0154) were found after endurance-strength exercise (group B). Conclusion: The mode of exercise does matter: endurance-strength exercise led to a greater improvement, compared to endurance exercise, in the liver function in women with abdominal obesity.

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KW - Liver function

KW - Obesity

KW - Physical exercise

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