Effects of ethanol on adenosine 5′-triphosphate-gated purinergic and 5-hydroxytryptamine 3 receptors

Daryl L. Davies, Liana Asatryan, Sacha T. Kuo, John J. Woodward, Brian F. King, Ronald L. Alkana, Cheng Xiao, Jiang Ye, Hui Sun, Li Zhang, Xiang Qun Hu, Volodya Hayrapetyan, David M. Lovinger, Tina K. Machu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This report of the proceedings of a symposium presented at the 2005 annual meeting of the Research Society on Alcoholism highlights the actions of ethanol on purinergic (P2XRs) and 5-hydroxytryptamine 3 (5-HT 3Rs) receptors. Both P2XRs and 5-HT 3Rs, are modulated by pharmacologically relevant concentrations of ethanol, with inhibition or stimulation of P2XR subtypes and stimulation of 5-HT 3Rs, respectively. With regard to ethanol-modulatory actions, these 2 distinctly different receptor classes have been studied to a much lesser extent than other LGICs. The organizers and chairs were Daryl L. Davies and Tina K. Machu. John J. Woodward discusses the molecular pharmacology and physiology of P2XRs and 5-HT 3Rs and sets the stage for a detailed investigation into the ethanol sensitivity of these channels by the invited speakers. Daryl L. Davies discusses the results from recent electrophysiological studies conducted in his and Dr. Woodward's laboratories, highlighting the actions of ethanol on P2XR subtypes. Jiang-Hong Ye discusses results from recent studies using loose-patch and whole-cell recordings on purinergic receptors expressed on neurons from the ventral tegmental area (VTA) in rats. Tina K. Machu discusses electrophysiological studies conducted in her and Dr. David Lovinger's laboratories on nonpore lining residues of the second transmembrane domain (TM2) of the 5-HT 3A receptor. Li Zhang presents data demonstrating that F-actin cytoskeletons play a critical role in 5-HT 3 receptor clustering in hippocampal neurons. Collectively, the presentations provided strong evidence that P2X and 5-HT 3 receptors are important targets for ethanol action.

Original languageEnglish (US)
Pages (from-to)349-358
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume30
Issue number2
DOIs
StatePublished - Feb 1 2006

Fingerprint

Receptors, Serotonin, 5-HT3
Adenosine
Serotonin
Ethanol
Adenosine Triphosphate
Serotonin Receptors
Neurons
Purinergic Receptors
Ventral Tegmental Area
Patch-Clamp Techniques
Actin Cytoskeleton
Physiology
Cluster Analysis
triphosphoric acid
Actins
Linings
Rats
Pharmacology

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Keywords

  • 5-HT Receptor
  • Alcohol
  • Ethanol
  • P2X receptor

Cite this

Davies, D. L., Asatryan, L., Kuo, S. T., Woodward, J. J., King, B. F., Alkana, R. L., ... Machu, T. K. (2006). Effects of ethanol on adenosine 5′-triphosphate-gated purinergic and 5-hydroxytryptamine 3 receptors. Alcoholism: Clinical and Experimental Research, 30(2), 349-358. https://doi.org/10.1111/j.1530-0277.2006.00023.x
Davies, Daryl L. ; Asatryan, Liana ; Kuo, Sacha T. ; Woodward, John J. ; King, Brian F. ; Alkana, Ronald L. ; Xiao, Cheng ; Ye, Jiang ; Sun, Hui ; Zhang, Li ; Hu, Xiang Qun ; Hayrapetyan, Volodya ; Lovinger, David M. ; Machu, Tina K. / Effects of ethanol on adenosine 5′-triphosphate-gated purinergic and 5-hydroxytryptamine 3 receptors. In: Alcoholism: Clinical and Experimental Research. 2006 ; Vol. 30, No. 2. pp. 349-358.
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Davies, DL, Asatryan, L, Kuo, ST, Woodward, JJ, King, BF, Alkana, RL, Xiao, C, Ye, J, Sun, H, Zhang, L, Hu, XQ, Hayrapetyan, V, Lovinger, DM & Machu, TK 2006, 'Effects of ethanol on adenosine 5′-triphosphate-gated purinergic and 5-hydroxytryptamine 3 receptors', Alcoholism: Clinical and Experimental Research, vol. 30, no. 2, pp. 349-358. https://doi.org/10.1111/j.1530-0277.2006.00023.x

Effects of ethanol on adenosine 5′-triphosphate-gated purinergic and 5-hydroxytryptamine 3 receptors. / Davies, Daryl L.; Asatryan, Liana; Kuo, Sacha T.; Woodward, John J.; King, Brian F.; Alkana, Ronald L.; Xiao, Cheng; Ye, Jiang; Sun, Hui; Zhang, Li; Hu, Xiang Qun; Hayrapetyan, Volodya; Lovinger, David M.; Machu, Tina K.

In: Alcoholism: Clinical and Experimental Research, Vol. 30, No. 2, 01.02.2006, p. 349-358.

Research output: Contribution to journalArticle

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T1 - Effects of ethanol on adenosine 5′-triphosphate-gated purinergic and 5-hydroxytryptamine 3 receptors

AU - Davies, Daryl L.

AU - Asatryan, Liana

AU - Kuo, Sacha T.

AU - Woodward, John J.

AU - King, Brian F.

AU - Alkana, Ronald L.

AU - Xiao, Cheng

AU - Ye, Jiang

AU - Sun, Hui

AU - Zhang, Li

AU - Hu, Xiang Qun

AU - Hayrapetyan, Volodya

AU - Lovinger, David M.

AU - Machu, Tina K.

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N2 - This report of the proceedings of a symposium presented at the 2005 annual meeting of the Research Society on Alcoholism highlights the actions of ethanol on purinergic (P2XRs) and 5-hydroxytryptamine 3 (5-HT 3Rs) receptors. Both P2XRs and 5-HT 3Rs, are modulated by pharmacologically relevant concentrations of ethanol, with inhibition or stimulation of P2XR subtypes and stimulation of 5-HT 3Rs, respectively. With regard to ethanol-modulatory actions, these 2 distinctly different receptor classes have been studied to a much lesser extent than other LGICs. The organizers and chairs were Daryl L. Davies and Tina K. Machu. John J. Woodward discusses the molecular pharmacology and physiology of P2XRs and 5-HT 3Rs and sets the stage for a detailed investigation into the ethanol sensitivity of these channels by the invited speakers. Daryl L. Davies discusses the results from recent electrophysiological studies conducted in his and Dr. Woodward's laboratories, highlighting the actions of ethanol on P2XR subtypes. Jiang-Hong Ye discusses results from recent studies using loose-patch and whole-cell recordings on purinergic receptors expressed on neurons from the ventral tegmental area (VTA) in rats. Tina K. Machu discusses electrophysiological studies conducted in her and Dr. David Lovinger's laboratories on nonpore lining residues of the second transmembrane domain (TM2) of the 5-HT 3A receptor. Li Zhang presents data demonstrating that F-actin cytoskeletons play a critical role in 5-HT 3 receptor clustering in hippocampal neurons. Collectively, the presentations provided strong evidence that P2X and 5-HT 3 receptors are important targets for ethanol action.

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