Effects of Ethanol on the Contractile Function of the Heart: A Review

Andrew P. Thomas, Dennis J. Rozanski, Dominique C. Renard, Emanuel Rubin

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


Chronic ethanol consumption leads to a number of alterations in the contractile function of the heart and is a leading cause of cardiomyopathy. Ethanol also has an acute negative inotropic effect mediated by direct interaction with cardiac muscle cells, although this action is often masked by indirect actions resulting from enhanced release of catecholamines in vivo. This article reviews the effects of ethanol on the contractile function of the heart. The specific targets affected by ethanol in cardiac muscle cells are discussed in terms of potential mechanisms underlying the depressions of contractility resulting from both acute and chronic actions of ethanol.

Original languageEnglish (US)
Pages (from-to)121-131
Number of pages11
JournalAlcoholism: Clinical and Experimental Research
Issue number1
StatePublished - Feb 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health


  • Calcium
  • Ethanol
  • Heart
  • Muscle Contraction

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