Effects of incubation time on in vitro self-assembly of type I collagen molecules

E. K. Huang, G. D. Pins, Frederick Silver, D. L. Christiansen

Research output: Contribution to conferencePaper

Abstract

The effects of incubation time on the in vitro self-assembly and fibrillogenesis of type I collagen fibers during fiber extrusion and incubation is studied. Preliminary results show that extending the incubation time of the collagen fibers during co-extrusion increases the ultimate tensile strength and the stiffness of self-assembled collagen fibers. A large decrease in hydrated diameters is observed between fibers that undergo two standard 24 hour incubation cycles and those that undergo a one week incubation cycle. Thus, increasing the incubation times enhance the mechanical properties of the fibers by increasing fibril diameters and creating more extensive lateral interactions.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Huang, E. K., Pins, G. D., Silver, F., & Christiansen, D. L. (1996). Effects of incubation time on in vitro self-assembly of type I collagen molecules. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .