Rats anesthetized with pentobarbital were exposed to gas mixtures of 80 and 160 parts/106 carbon monoxide in air for twenty minute periods. Tissue oxygen tension (Po2) was measured polarographically in the biceps brachii muscle and the cerebral cortex during the course of the exposure. Heart rate was recorded before and after each trial. At 80 parts/106 CO a fall of 0.8 mmHg from an initial value of 20.2 mmHg Po2 was found in the muscle. A decrease that was not statistically significant occurred in the brain. At 160 parts/106 CO a significant decline of 0.7 mmHg was found in the brain, falling from 11.3 mmHg, and the muscle value fell 1.4 mmHg from an initial value of 20.6 mmHg. At each carbon monoxide exposure level, the percentage declines in brain and muscle tissue Po2 were approximately the same. No change in heart rate occurred at either level of carbon monoxide exposure. At the conclusion of the experiment, the percentage carboxyhemoglobin had risen to an average of 3.3%.
|Original language||English (US)|
|Number of pages||9|
|State||Published - Dec 1 1974|
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