Effects of scopolamine on activity and passive avoidance learning in rats of different ages

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40 Scopus citations

Abstract

A total of 320 albino CFE Sprague-Dawley rats aged 16-17, 20-21, 24-25, 28-29, and 70-85 days old were injected intraperitoneally with either scopolamine hydrobromide (SCOP-HBr) or scopolamine methylnitrate (SCOP-Me-NO-3) at 4 levels (0, .5, 1.9, or 2.0 mg/kg. The SCOP-HBr but not he SCOP-Me-NO-3 disrupted passive avoidance in Ss aged 20-28 days. A subsequent replication at higher doses (4.0, 8.0, and 16.0 mg/kg) with 56 70-84 day old adults and 64 16-day-old pups indicated that SCOP-HBr could disrupt passive avoidance in the adults but not in the pups. Results are consistent with the hypothesis that a cholinergic inhibitory system which mediates passive avoidance develops in the rat 16-20 days postnatally. (29 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Original languageEnglish (US)
Pages (from-to)26-36
Number of pages11
JournalJournal of comparative and physiological psychology
Volume87
Issue number1
DOIs
StatePublished - Jul 1974
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • 20-21 &
  • 24-25 &
  • 28-29 &
  • 70-85 day old rats
  • scopolamine hydrobromide &
  • scopolamine methylnitrate, passive avoidance learning, 16-17 &

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