Effects of sequence, cyclization, and superhelical stress on the internal motions of DNA

Atsushi Matsumoto, Wilma K. Olson

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The large-scale fluctuations of DNA are key to understanding kinetically complicatedmolecular events, such as the ease of the long, double helical polymer snaking through the pores of a gel or closing into a loop between separately boundr egulatory proteins. DNA loop formation is implicated, in turn, in a number of important biological processes, including the regulation of transcription [1, 2] andthe organization of chromatin [3-5]. The base-pair sequence plays a critical role in these processes, helping to guide the overall folding of the chain molecule [6-8] and determining the responses of the double helix to superhelical stress, References 9 and 10.

Original languageEnglish (US)
Title of host publicationNormal Mode Analysis
Subtitle of host publicationTheory and Applications to Biological and Chemical Systems
PublisherCRC Press
Pages187-211
Number of pages25
ISBN (Electronic)9781420035070
ISBN (Print)158488472X, 9781584884729
StatePublished - Jan 1 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Mathematics(all)
  • Chemistry(all)

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