Effects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferation

Hongyan Wang, Qianben Wang, Rakesh K. Srivastava, Shu Sheng Gong, Lixing Lao, Joseph D. Fondell, Jiam Bei Wang

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Baishouwu (Cynanchum Auriculalum Royle ex Wight), a traditional Chinese herbal medicine, is used as a traditional anti-aging remedy in China. Previous studies suggested Baishouwu has multiple pharmacological actions. In this study, the total glycosides extracted from Baishouwu (CA/TG) were evaluated for its potential anti-tumor activity and mechanism on several human breast and prostate cancer cell lines. In [3H] thymidine incorporation assay, CA/TG inhibited the proliferation of cancer cells in a dose-dependent fashion. It also displayed anti-androgen activity on androgen sensitive cell line assessed by reporter gene assay. The morphological examination of CA/TG treated cells revealed overall shrinkage of nucleus, chromatin condensation and small nuclear fragments by DAPI staining, the characteristic pattern of DNA ladders were observed in cells exposed to CA/TG, indicating the involvement of apoptosis in its action. These results suggested that the CA/TG has preferred cytotoxicity against the cancer cells, and the action was due to its ability of preventing cell proliferation and inducing apoptosis.

Original languageEnglish (US)
Pages (from-to)62-66
Number of pages5
JournalAlternative Therapies in Health and Medicine
Volume9
Issue number5
StatePublished - Sep 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

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