Efferent Vestibular System: Anatomy, Physiology, and Neurochemistry

Jay M. Goldberg, Alan M. Brichta, Phillip A. Wackym

Research output: Chapter in Book/Report/Conference proceedingChapter


Most efferent vestibular neurons contain choline acetyltransferase and acetylcholinesterase. The labeling of the efferent neurons was an important step that led within a few years to studies of the effects of efferent stimulation on afferent discharge, as well as to later studies of the neurochemistry of efferent transmission. This chapter considers the locations of efferent cell bodies in mammals and compares the results with those obtained in other vertebrate species. The course of the efferent axons from the brain stem to the ear will only be described in mammals. There are striking variations in the efferent responses of afferents innervating different parts of the neuroepithelium and differing in their responses to natural stimulation. To understand the diversity of efferent responses, one need to consider the regional organization of the endorgans. Since the organization differs across species, separate sections are devoted to mammals, toadfish, and turtles. The chapter also reviews the role of substances that may function as efferent neurotransmitters.

Original languageEnglish (US)
Title of host publicationNeurochemistry of the Vestibular System
PublisherCRC Press
Number of pages34
ISBN (Electronic)9781351428903
ISBN (Print)9780849376795
StatePublished - Jan 1 2023

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Neuroscience(all)


Dive into the research topics of 'Efferent Vestibular System: Anatomy, Physiology, and Neurochemistry'. Together they form a unique fingerprint.

Cite this