Efficacy and Safety of Lumen-Apposing Metal Stents in Management of Pancreatic Fluid Collections: Are They Better Than Plastic Stents? A Systematic Review and Meta-Analysis

Tariq Hammad, Muhammad Ali Khan, Yaseen Alastal, Wade Lee, Ali Nawras, Mohammad Kashif Ismail, Michel Kahaleh

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Background and Aims: Endoscopic ultrasound (EUS)-guided transmural drainage has been increasingly utilized as a first-line therapeutic modality for drainage of pancreatic fluid collections (PFC). Recently, lumen-apposing metal stents (LAMS) have been utilized for management of PFCs. We conducted a systematic review and meta-analysis to evaluate the cumulative efficacy and safety of LAMS in the management of PFC (primary outcome). We also compared the efficacy and safety of LAMS with multiple plastic stents (MPS) in the management of PFC (secondary outcome). Methods: We searched Medline, Embase and Cochrane databases from inception to November 5, 2016, to identify studies (with ≥ 10 patients) reporting technical success, clinical success, and adverse events (AE) of EUS-guided transmural drainage of PFC using LAMS. Weighted pooled rates (WPR) were calculated for technical success, clinical success and AE. Risk ratios (RR) were calculated and pooled to compare LAMS with MPS in terms of technical success, clinical success, and AE. Pooled mean difference (MD) was calculated to compare the number of endoscopic sessions required by each type of stent to achieve clinical success. All analyses were done using random effects model. Results: Eleven studies with 688 patients were included in this meta-analysis. WPR for technical success of LAMS in PFC management was 98% (96, 99%), (I2 = 15%). WPR for clinical success was 93% (89, 96%) with moderate heterogeneity (I2 = 50%). There was no difference in clinical success for pseudocysts (PP) versus walled-off pancreatic necrosis (WON) (P = 0.51). WPR for AE was 13% (9, 20%), (I2 = 64%). AE were 10% more in WON as compared to PP (P = 0.009). Most common AE requiring intervention was stent migration (4.2%), followed by infection (3.8%), bleeding (2.4%), and stent occlusion (1.9%). Six studies with 504 patients compared the performance of LAMS with MPS. Pooled RR for technical success was 1.71 (0.38, 7.37). Pooled RR for clinical success was 0.37 (0.20, 0.67) in favor of LAMS. Pooled RR for AE was 0.39 (0.18, 0.84), (I2 = 50%). Pooled MD for number of endoscopic sessions was − 0.84 (− 1.69, 0.01). Conclusions: LAMS seem to have excellent efficacy and safety in the management of PFCs. They may be preferred over plastic stents as they are associated with better clinical success and lesser adverse events.

Original languageEnglish (US)
Pages (from-to)289-301
Number of pages13
JournalDigestive diseases and sciences
Volume63
Issue number2
DOIs
StatePublished - Feb 1 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Keywords

  • EUS
  • Lumen-apposing metal stents
  • Pancreatic fluid collections
  • Pancreatic pseudocysts
  • Plastic stents
  • Walled-off necrosis

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