Efficacy of simultaneous pericranial and nasoseptal “double flap” reconstruction of anterior skull base defects after combined transbasal and endoscopic endonasal approaches

Phabinly J. Gabriel, Gurkirat Kohli, Wayne D. Hsueh, Jean Anderson Eloy, James K. Liu

Research output: Contribution to journalArticle


Abstract: Background: The “double flap” reconstruction technique, comprised of a simultaneous vascularized pedicled pericranial flap (PCF) and pedicled nasoseptal flap (NSF), can be used to repair anterior skull base defects after a combined cranionasal or transbasal-endoscopic endonasal approach (EEA) has been performed to remove malignant anterior skull base tumors. The use of two vascularized flaps may potentially decrease the incidence of post-radiation flap necrosis and postoperative cerebrospinal fluid (CSF) leaks after radiation therapy. Methods: We conducted a retrospective review of a prospective skull base database on patients who underwent the double flap reconstruction technique after a combined transbasal-EEA approach. Data collected for each patient included demographics, method of tumor resection and repair, complications, tumor recurrence, and follow-up. Results: Nine patients who underwent a combined transbasal-EEA approach for resection of anterior skull base tumors with significant intracranial extension followed by reconstruction of the cranial base using the double flap technique. Four were men and five were women, with a mean age of 49 years (range, 15–68 years). There was no postoperative CSF leakage detected or complications of infection, meningitis, mucocele, or tension pneumocephalus after a mean follow-up of 35.7 months (range, 4.5–98 months). Seven of the nine patients underwent adjuvant radiation without flap necrosis. Local tumor recurrence was not observed in any of the patients at last follow-up; however, one patient developed distant brain metastasis. Conclusion: The simultaneous PCF and NSF double flap reconstruction is an effective technique in preventing postoperative CSF leakage and post-radiation necrosis when repairing anterior skull base defects after combined transbasal-EEA approaches. This technique may be useful in patients anticipated to undergo postoperative radiation therapy.

Original languageEnglish (US)
Pages (from-to)641-647
Number of pages7
JournalActa Neurochirurgica
Issue number3
StatePublished - Mar 1 2020


All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology


  • Combined cranionasal approach
  • Double flap
  • Nasoseptal flap
  • Pericranial flap
  • Skull base reconstruction

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