Processors and operating systems (OSes) support multiple memory page sizes. Superpages increase Translation Lookaside Buffer (TLB) hits, while small pages provide fine-grained memory protection. Ideally, TLBs should perform well for any distribution of page sizes. In reality, set-associative TLBs - used frequently for their energyefficiency compared to fully-associative TLBs - cannot (easily) support multiple page sizes concurrently. Instead, commercial systems typically implement separate set-associative TLBs for different page sizes. This means that when superpages are allocated aggressively, TLB misses may, counterintuitively, increase even if entries for small pages remain unused (and vice-versa). We invent MIX TLBs, energy-frugal set-associative structures that concurrently support all page sizes by exploiting superpage allocation patterns. MIX TLBs boost the performance (often by 10-30%) of big-memory applications on native CPUs, virtualized CPUs, and GPUs. MIX TLBs are simple and require no OS or program changes.