Efficient new approach for the synthesis of N,N-dialkylamino-1,2,4-triazoles

Qiang Zhang; Youyi Peng; William J. Welsh

doi:10.3987/COM-06-10886

Efficient new approach for the synthesis of N,N-dialkylamino-1,2,4-triazoles

Qiang Zhang, Youyi Peng, William J. Welsh

Robert Wood Johnson Medical School (RWJMS), Pharmacology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A series of 3-NN-dialkylamino-4,5-diaryl-1,2,4-triazoles were synthesized in high yield under mild reaction conditions by coupling functionalized arylmagnesiums with isothiocyanates and cyclization with Viehe's salts. No selective thionation reaction was required for the preparation of carbamoyl derivatives.{A figure is presented}. Triazole Viehe's Salt Cyclization Thionation Grignard Reagent.

Original language	English (US)
Pages (from-to)	2635-2645
Number of pages	11
Journal	Heterocycles
Volume	68
Issue number	12
DOIs	https://doi.org/10.3987/COM-06-10886
State	Published - Dec 1 2006

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "A series of 3-NN-dialkylamino-4,5-diaryl-1,2,4-triazoles were synthesized in high yield under mild reaction conditions by coupling functionalized arylmagnesiums with isothiocyanates and cyclization with Viehe's salts. No selective thionation reaction was required for the preparation of carbamoyl derivatives.{A figure is presented}. Triazole Viehe's Salt Cyclization Thionation Grignard Reagent.",

author = "Qiang Zhang and Youyi Peng and Welsh, {William J.}",

year = "2006",

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doi = "10.3987/COM-06-10886",

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AU - Zhang, Qiang

AU - Peng, Youyi

AU - Welsh, William J.

PY - 2006/12/1

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N2 - A series of 3-NN-dialkylamino-4,5-diaryl-1,2,4-triazoles were synthesized in high yield under mild reaction conditions by coupling functionalized arylmagnesiums with isothiocyanates and cyclization with Viehe's salts. No selective thionation reaction was required for the preparation of carbamoyl derivatives.{A figure is presented}. Triazole Viehe's Salt Cyclization Thionation Grignard Reagent.

AB - A series of 3-NN-dialkylamino-4,5-diaryl-1,2,4-triazoles were synthesized in high yield under mild reaction conditions by coupling functionalized arylmagnesiums with isothiocyanates and cyclization with Viehe's salts. No selective thionation reaction was required for the preparation of carbamoyl derivatives.{A figure is presented}. Triazole Viehe's Salt Cyclization Thionation Grignard Reagent.

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JF - Heterocycles

IS - 12

ER -

Efficient new approach for the synthesis of N,N-dialkylamino-1,2,4-triazoles

Abstract

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