Elastic mechanical properties of cardiac myocyte membranes

Judith Redling, Dennis Harris, William Craelius

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The elasticity of the cardiac myocyte membrane has been evaluated in terms of membrane stiffness and elastic moduli defined by area compressibility and shear strain. Preliminary results for the patch clamp method of measurement, whereby negative pressure is applied to the membrane in the 10-60 mmHg range, demonstrate a remarkably linear stiffness index for cardiac myocytes, accompanied by relatively discrete elastic moduli (relative to two types of seals). Realization of the cardiac myocyte elastic moduli may provide a mechanical basis for a potential relationship between the myocyte membrane and the cytoskeleton, as well as underlying implications of the effects of mechanical forces on the electrical activation of the heart.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual Conference on Engineering in Medicine and Biology
PublisherPubl by IEEE
Pages2056-2057
Number of pages2
Editionpt 5
ISBN (Print)0780302168
StatePublished - 1991
EventProceedings of the 13th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Orlando, FL, USA
Duration: Oct 31 1991Nov 3 1991

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 5
Volume13
ISSN (Print)0589-1019

Other

OtherProceedings of the 13th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityOrlando, FL, USA
Period10/31/9111/3/91

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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