Elderly women regulate brain blood flow better than men do

Brian M. Deegan, Farzaneh A. Sorond, Andrew Galica, Lewis A. Lipsitz, Gearoid O'Laighin, Jorge M. Serrador

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background and Purpose- Orthostatic intolerance and falls differ between sexes and change with age. However, it remains unclear what role cerebral autoregulation may play in this response. This study was designed to determine whether cerebral autoregulation, assessed using transcranial Doppler ultrasound, is more effective in elderly females than in males. Methods- We used transcranial Doppler ultrasound to evaluate cerebral autoregulation in 544 (236 male) subjects older than age 70 years recruited as part of the MOBILIZE Boston study. The MOBILIZE Boston study is a prospective cohort study of a unique set of risk factors for falls in seniors in the Boston area. We assessed CO2 reactivity and transfer function gain, phase, and coherence during 5 minutes of quiet sitting and autoregulatory index during sit-to-stand tests. Results- Male subjects had significantly lower CO2 reactivity (males, 1.10±0.03; females, 1.32±0.43 (cm/s)/%CO2; P<0.001) and autoregulatory indices (males, 4.41±2.44; female, 5.32±2.47; P<0.001), higher transfer function gain (males, 1.34±0.49; females, 1.19±0.43; P=0.002), and lower phase (males, 42.7±23.6; females, 49.4±24.9; P=0.002) in the autoregulatory band, implying less effective cerebral autoregulation. However, reduced autoregulation in males was not below the normal range, indicating autoregulation was intact but less effective. Conclusions- Female subjects were better able to maintain cerebral flow velocities during postural changes and demonstrated better cerebral autoregulation. The mechanisms of sex-based differences in autoregulation remain unclear but may partially explain the higher rates of orthostatic hypotension-related hospitalizations in elderly men.

Original languageEnglish (US)
Pages (from-to)1988-1993
Number of pages6
JournalStroke
Volume42
Issue number7
DOIs
StatePublished - Jul 1 2011

Fingerprint

Homeostasis
Brain
Doppler Ultrasonography
Orthostatic Intolerance
Orthostatic Hypotension
Sex Characteristics
Reference Values
Hospitalization
Cohort Studies
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Keywords

  • blood pressure
  • cerebral autoregulation
  • cerebral blood flow
  • sex

Cite this

Deegan, B. M., Sorond, F. A., Galica, A., Lipsitz, L. A., O'Laighin, G., & Serrador, J. M. (2011). Elderly women regulate brain blood flow better than men do. Stroke, 42(7), 1988-1993. https://doi.org/10.1161/STROKEAHA.110.605618
Deegan, Brian M. ; Sorond, Farzaneh A. ; Galica, Andrew ; Lipsitz, Lewis A. ; O'Laighin, Gearoid ; Serrador, Jorge M. / Elderly women regulate brain blood flow better than men do. In: Stroke. 2011 ; Vol. 42, No. 7. pp. 1988-1993.
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Deegan, BM, Sorond, FA, Galica, A, Lipsitz, LA, O'Laighin, G & Serrador, JM 2011, 'Elderly women regulate brain blood flow better than men do', Stroke, vol. 42, no. 7, pp. 1988-1993. https://doi.org/10.1161/STROKEAHA.110.605618

Elderly women regulate brain blood flow better than men do. / Deegan, Brian M.; Sorond, Farzaneh A.; Galica, Andrew; Lipsitz, Lewis A.; O'Laighin, Gearoid; Serrador, Jorge M.

In: Stroke, Vol. 42, No. 7, 01.07.2011, p. 1988-1993.

Research output: Contribution to journalArticle

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Deegan BM, Sorond FA, Galica A, Lipsitz LA, O'Laighin G, Serrador JM. Elderly women regulate brain blood flow better than men do. Stroke. 2011 Jul 1;42(7):1988-1993. https://doi.org/10.1161/STROKEAHA.110.605618