Electrical detection of protein biomarkers using nanoneedle biosensors

Rahim Esfandyarpour, Hesaam Esfandyarpour, Mehdi Javanmard, James S. Harris, Ronald W. Davis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations


Here we present the development of an array of electrical nano-biosensors in a microfluidic channel, called Nanoneedle biosensors. Then we present the proof of concept study for protein detection. A Nanoneedle biosensor is a real-time, label-free, direct electrical detection platform, which is capable of high sensitivity detection, measuring the change in ionic current and impedance modulation, due to the presence or reaction of biomolecules such as proteins or nucleic acids. We show that the sensors which have been fabricated and characterized for the protein detection. We have functionalized Nanoneedle biosensors with receptors specific to a target protein using physical adsorption for immobilization. We have used biotinylated bovine serum albumin as the receptor and sterptavidin as the target analyte. The detection of streptavidin binding to the receptor protein is also presented.

Original languageEnglish (US)
Title of host publicationMEMS, BioMEMS and Bioelectronics - Materials and Devices
Number of pages8
Publication statusPublished - Aug 20 2012
Externally publishedYes
Event2011 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 28 2011Dec 2 2011

Publication series

NameMaterials Research Society Symposium Proceedings
ISSN (Print)0272-9172


Other2011 MRS Fall Meeting
CountryUnited States
CityBoston, MA


All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Esfandyarpour, R., Esfandyarpour, H., Javanmard, M., Harris, J. S., & Davis, R. W. (2012). Electrical detection of protein biomarkers using nanoneedle biosensors. In MEMS, BioMEMS and Bioelectronics - Materials and Devices (pp. 181-188). (Materials Research Society Symposium Proceedings; Vol. 1415). https://doi.org/10.1557/opl.2012.807